[4-(3-fluoro-4-phenylethynylphenylethynyl)-3-trifluoromethylphenylethynyl]trimethylsilane

Base Information

Chemical Name:[4-(3-fluoro-4-phenylethynylphenylethynyl)-3-trifluoromethylphenylethynyl]trimethylsilane
CAS No.:518342-83-1
Molecular Formula:C₂₈H₂₀F₄Si
Molecular Weight:460.546
Hs Code.:

Synonyms:[4-(3-fluoro-4-phenylethynylphenylethynyl)-3-trifluoromethylphenylethynyl]trimethylsilane

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Chemical Property of [4-(3-fluoro-4-phenylethynylphenylethynyl)-3-trifluoromethylphenylethynyl]trimethylsilane

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Technology Process of [4-(3-fluoro-4-phenylethynylphenylethynyl)-3-trifluoromethylphenylethynyl]trimethylsilane

There total 11 articles about [4-(3-fluoro-4-phenylethynylphenylethynyl)-3-trifluoromethylphenylethynyl]trimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 518342-71-7
4-ethynyl-2-fluoro-1-(phenylethynyl)benzene

: 518342-66-0
((4-iodo-3-trifluoromethylphenyl)ethynyl)trimethylsilane

: 518342-83-1
[4-(3-fluoro-4-phenylethynylphenylethynyl)-3-trifluoromethylphenylethynyl]trimethylsilane

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 50 ℃; for 168h;
DOI:10.1016/S0040-4020(02)01409-6

Reference yield:

: 518342-61-5
2-trifluoromethyl-4-(trimethylsilylethynyl)aniline

: 518342-83-1
[4-(3-fluoro-4-phenylethynylphenylethynyl)-3-trifluoromethylphenylethynyl]trimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1.1: BF₃*Et₂O; t-BuONO / diethyl ether / -20 - 5 °C

1.2: 67 percent / NaI; I₂ / acetonitrile / 1 h / 20 °C

With tert.-butylnitrite; boron trifluoride diethyl etherate; In diethyl ether;
DOI:10.1016/S0040-4020(02)01409-6

Reference yield:

: 97760-97-9
4-iodo-2-(trifluoromethyl)aniline

: 518342-83-1
[4-(3-fluoro-4-phenylethynylphenylethynyl)-3-trifluoromethylphenylethynyl]trimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1.1: Pd(PPh₃)2Cl₂; CuI; triethylamine / 20 °C

2.1: BF₃*Et₂O; t-BuONO / diethyl ether / -20 - 5 °C

2.2: 67 percent / NaI; I₂ / acetonitrile / 1 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tert.-butylnitrite; boron trifluoride diethyl etherate; triethylamine; In diethyl ether; 1.1: Sonogashira coupling;
DOI:10.1016/S0040-4020(02)01409-6