97760-97-9

Basic information

• Product Name: 2-AMINO-5-IODOBENZOTRIFLUORIDE
• Synonyms: 4-IODO-2-(TRIFLUOROMETHYL)ANILINE;2-AMINO-5-IODOBENZOTRIFLUORIDE;ASISCHEM Z25859;2-Amino-5-iodobenzotrifluoride 98%;2-Amino-5-iodobenzotrifluoride98%;4-iodo-2-(trifluoromethyl)benzenamine;4-Iodo-2-trifluoromethylphenylamine;4-Iodo-2-(trifluoromethyl)aniline, 4-Iodo-alpha,alpha,alpha-trifluoro-o-toluidine
• CAS NO: 97760-97-9
• Molecular Formula: C₇H₅F₃IN
• Molecular Weight: 287.02
• Product Categories: Amines;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 97760-97-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 262℃
• Flash Point: 112℃
• Appearance: /
• Density: 1.948
• Vapor Pressure: 0.0112mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 2-AMINO-5-IODOBENZOTRIFLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-IODOBENZOTRIFLUORIDE(97760-97-9)
• EPA Substance Registry System: 2-AMINO-5-IODOBENZOTRIFLUORIDE(97760-97-9)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 97760-97-9(Hazardous Substances Data)

Usage

Uses

4-Iodo-2-trifluoromethylaniline

InChI:InChI=1/C7H5F3IN/c8-7(9,10)5-3-4(11)1-2-6(5)12/h1-3H,12H2

Upstream product

• 887144-94-7 Togni's reagent II 
• 540-37-4 p-aminoiodobenzene 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 2314-97-8 iodotrifluoromethane 
• 796068-66-1 N-(4-iodo)phenylpicolinamide 

Downstream Products

• 97760-98-0 N-(4-iodo-2-(trifluoromethyl)phenyl)acetamide 
• 1366131-91-0 4-fluoro-6-iodo-3-phenyl-2-quinolinamine 
• 1366131-97-6 3-[4-bromo-2-(methyloxy)phenyl]-4-fluoro-6-iodo-2-quinolinamine 
• 1366131-92-1 2-amino-6-iodo-3-phenyl-4-quinolinecarbonitrile 
• 1366131-93-2 6-iodo-4-(methylsulfinyl)-3-phenyl-2-quinolinamine 
• 1366131-94-3 6-iodo-4-(methylthio)-3-phenyl-2-quinolinamine 
• 1366130-08-6 N-[5-{2-amino-3-[4-bromo-2-(methyloxy)phenyl]-4-cyano-6-quinolinyl}-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide 
• 1366132-22-0 6-iodo-4-methoxy-3-phenylquinolin-2-amine 
• 327-74-2 4-cyano-2-trifluoromethylaniline 
• 97804-09-6 diethyl 2-(4-amino-3-bromo-5-trifluoromethyl-benzoyl)-malonate 
• 97776-04-0 diethyl 2-(4-amino-3-chloro-5-trifluoromethyl-benzoyl)-malonate 
• 97760-75-3 N-(4-acetyl-2-(trifluoromethyl)phenyl)acetamide 
• 175277-96-0 N-(4-cyano-2-(trifluoromethyl)phenyl)acetamide 
• 97776-05-1 4-amino-3-bromo-5-trifluoromethyl-benzoic acid 

Relevant articles and documents

Transition metal-free direct C–H trifluoromethyltion of (hetero)arenes with Togni's reagent

A new transition-metal-free direct C–H trifluoromethylation reaction of (hetero)arenes with Togni's reagent was developed. This transformation proceeded smoothly under mild conditions and exhibited good tolerance of many synthetically relevant functional groups. It provided an alternative approach for the synthesis of trifluoromethylated (hetero)arenes.

Coordinating Activation Strategy-Induced Selective C?H Trifluoromethylation of Anilines

A simple protocol for the synthesis of 2-(trifluoromethyl)aniline derivatives through a coordinating activation strategy was developed. The reaction showed good reactivity and gave the target products in moderate to good yields. Pleasingly, the directing group could be recovered in excellent yield. Furthermore, this strategy allowed efficient access to the synthesis of floctafenine. A single-electron-transfer mechanism was proposed to be responsible for this trifluoromethylation reaction.

Preparation method of trifluoromethylamine

The invention relates to a preparation method of trifluoromethylamine. The method includes the following steps that aromatic amine shown in the formula (1) and a trifluoromethyl reagent shown in the formula (2) react in a solvent under the condition that an alkali and/or nickel compound exists, and the trifluoromethylamine compound shown in the formula (3) is generated. According to the preparation method of trifluoromethylamine, aromatic amine and 1-trifluoromethyl-1,2-iodobenzoyl-3(H)-ketone serve as raw materials and react under the condition that the alkali and/or nickel compound exists through the amino positioning effect on aromatic nucleus. The synthesis steps of the method are simple, the cost of the raw materials is low, the production cost of trifluoromethylamine can be greatly reduced, and large-scale industrialized production is promoted.