Technology Process of (2E)-ethyl 3-(3-(1,4-dihydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-methylphenyl)acrylate
There total 10 articles about (2E)-ethyl 3-(3-(1,4-dihydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-methylphenyl)acrylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrabutylammomium bromide; palladium diacetate; sodium carbonate;
In
water;
at 20 - 150 ℃;
for 0.333333h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: aluminum (III) chloride / dichloromethane / 0.08 h / 0 °C
1.2: 0.5 h / 0 °C
2.1: toluene-4-sulfonic acid / methanol / 24 h / Reflux; Inert atmosphere
3.1: methyllithium lithium bromide / tert-butyl methyl ether; diethyl ether / 1 h / 20 °C / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
4.2: 3.33 h / -78 - 20 °C / Inert atmosphere
4.3: 0.5 h
5.1: tetrabutylammomium bromide; sodium carbonate; palladium diacetate / water / 0.33 h / 20 - 150 °C / Inert atmosphere
With
aluminum (III) chloride; n-butyllithium; methyllithium lithium bromide; tetrabutylammomium bromide; palladium diacetate; sodium carbonate; toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; tert-butyl methyl ether; water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: aluminum (III) chloride / 2.75 h / 0 - 55 °C
2.1: aluminum (III) chloride / dichloromethane / 0.08 h / 0 °C
2.2: 0.5 h / 0 °C
3.1: toluene-4-sulfonic acid / methanol / 24 h / Reflux; Inert atmosphere
4.1: methyllithium lithium bromide / tert-butyl methyl ether; diethyl ether / 1 h / 20 °C / Inert atmosphere
5.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
5.2: 3.33 h / -78 - 20 °C / Inert atmosphere
5.3: 0.5 h
6.1: tetrabutylammomium bromide; sodium carbonate; palladium diacetate / water / 0.33 h / 20 - 150 °C / Inert atmosphere
With
aluminum (III) chloride; n-butyllithium; methyllithium lithium bromide; tetrabutylammomium bromide; palladium diacetate; sodium carbonate; toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; tert-butyl methyl ether; water;
