29020-85-7

Usage

Chemical structure

1,1,4,4,7-pentamethyl-3,4-dihydronaphthalen-2(1H)-one is a chemical compound with a bulky, branched structure.

Classification

It is classified as a ketone.

Industry use

Commonly used in the fragrance industry as a key ingredient in perfumes and other scented products.

Odor

Has a strong, musky odor.

Longevity

Known for its long-lasting scent.

Aromatic properties

Due to its unique aromatic properties, it is often used to add a warm, woody note to fragrances.

Potential applications

May have potential applications in the pharmaceutical and cosmetic industries for its aroma-enhancing and masking properties.

Role in scent creation

Plays an important role in the creation of many popular and distinct scents.

Upstream product

• 5455-94-7 2,2,5,5-tetramethyltetrahydro-3-oxofuran 
• 108-88-3 toluene 

Downstream Products

• 1427690-55-8 2-fluoro-4-(1-(1,4-dihydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoic acid 
• 1427690-57-0 methyl 2-fluoro-4-(1-(1,4-dihydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoate 
• 1427690-49-0 (2E)-3-(3-(1,4-dihydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic acid 
• 1427690-51-4 (2E)-ethyl 3-(4-acetoxy-3-(1,4-dihydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)phenyl)acrylate 
• 1427690-47-8 (2E)-3-(3-(1,4-dihydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-methylphenyl)acrylic acid 
• 1427690-48-9 (2E)-ethyl 3-(3-(1,4-dihydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-methylphenyl)acrylate 
• 364626-82-4 5,8-dihydro-3,5,5,8,8-pentamethylnaphthalen-2-yl-2-boronic acid 
• 364626-70-0 4-[(3,5,5,8,8-tetramethyl-2-5,8-dihydronaphthyl)carbonyl]benzoic acid 
• 364626-69-7 4-[(3,5,5,8,8-tetramethyl-2-5,8-dihydronaphthyl)carbonyl]benzenecarbonitrile 
• 364626-67-5 6-bromo-1,1,4,4,7-pentamethyl-1,4-dihydronaphthalene 
• 1427690-32-1 (E)-1-(6-bromo-3,4-dihydro-1,1,4,4,7-pentamethylnaphthalen-2(1H)-ylidene)-2-tosylhydrazine 
• 167958-81-8 methyl 4-<(<6,7-3H>-3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)carbonyl>benzoate 
• 167958-82-9 methyl 4-<1-(<6,7-3H>-3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphth-2-yl)ethenyl>benzoate 
• 153559-45-6 methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate 

Relevant academic research and scientific papers

THERAPEUTIC COMPOUNDS

The invention provides compounds of formulae (I), (II), (III), and (IV): and salts thereof, as well as pharmaceutical compositions comprising such compounds. The compounds are useful for treating cancers and Alzheimer's disease.

Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR) selective agonists: Novel analogues of 4-[1-(3,5,5,8,8- Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,

Three unreported analogues of 4-[1-(3,5,5,8,8-pentamethyl-5-6-7-8- tetrahydro-2-naphthyl)ethynyl]benzoic acid (1), otherwise known as bexarotene, as well as four novel analogues of (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6- pentamethylnaphthalen-7-yl)-4-hydr

Syntheses of isotopically labeled 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro- 2-naphthyl)ethenyl]benzoic acid (LGD1069), a potent retinoid X receptor-selective ligand

LGD1069, 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl] benzoic acid, is the first retinoid X receptor (RXR) selective retinoid to enter clinical trials for treatment of dermatological diseases and cancer. In order to examine biological properties such as receptor binding, metabolism and bioavailability, [13C]-, [14C]-, and [3H]-labeled LGD1069 is required. Herein, we describe synthetic methods for preparing isotopically labeled homologs of LGD 1069 as well as comparative competition binding data for [6,7-3H]-LGD1069 and [3H]-9-cis retinoic acid with RXR active retinoids. The final radiolabeled products, [6,7-3H]-LGD1069 and 3-[14C]-LGD1069 have specific activities of 56 Ci/mmol and 49 mCi/mmol, respectively. Radiochemical purities are 99.5% for [6,7-3H]-LGD1069 and 99.0% for 3-[14C]-LGD1069. The chemical purity is 99.0% for 3-[13CD3]-LGD1069. Competition binding studies with known retinoids show similar K(d) values when either [6,7-3H]-LGD1069 or [3H]-9-cis retinoic acid is used as the radioligand.