(S)-1-(5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorophenyl)-2-nitroethanol

Base Information

Chemical Name:(S)-1-(5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorophenyl)-2-nitroethanol
CAS No.:1444767-39-8
Molecular Formula:C₁₄H₁₈FNO₆
Molecular Weight:315.298
Hs Code.:

Synonyms:(S)-1-(5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorophenyl)-2-nitroethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorophenyl)-2-nitroethanol

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Technology Process of (S)-1-(5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorophenyl)-2-nitroethanol

There total 4 articles about (S)-1-(5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorophenyl)-2-nitroethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 75-52-5
nitromethane

: (S)-5-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorobenzaldehyde

: 1444767-39-8
(S)-1-(5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorophenyl)-2-nitroethanol

Guidance literature:: With (1R)-1,7,7-trimethyl-N-(pyridin-2-ylmethyl)bicyclo[2.2.1]heptan-2-amine; copper diacetate; N-ethyl-N,N-diisopropylamine; In ethanol; at -40 - 20 ℃; for 25h;

Reference yield:

: 103438-84-2
methyl 2-amino-3-(2-fluoro-5-hydroxyphenyl)propanoate

: 1444767-39-8
(S)-1-(5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorophenyl)-2-nitroethanol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 16 h / 70 °C

2: (1R)-1,7,7-trimethyl-N-(pyridin-2-ylmethyl)bicyclo[2.2.1]heptan-2-amine; copper diacetate; N-ethyl-N,N-diisopropylamine / ethanol / 25 h / -40 - 20 °C

With (1R)-1,7,7-trimethyl-N-(pyridin-2-ylmethyl)bicyclo[2.2.1]heptan-2-amine; copper diacetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In ethanol; dimethyl sulfoxide;

Reference yield:

: 23788-74-1,7305-59-1
(R)-2,2-dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate

: 1444767-39-8
(S)-1-(5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorophenyl)-2-nitroethanol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 16 h / 70 °C

2: (1R)-1,7,7-trimethyl-N-(pyridin-2-ylmethyl)bicyclo[2.2.1]heptan-2-amine; copper diacetate; N-ethyl-N,N-diisopropylamine / ethanol / 25 h / -40 - 20 °C

With (1R)-1,7,7-trimethyl-N-(pyridin-2-ylmethyl)bicyclo[2.2.1]heptan-2-amine; copper diacetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In ethanol; dimethyl sulfoxide;