(S)-2-(dibenzylamino)-1-(5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorophenyl)ethanol

Base Information

Chemical Name:(S)-2-(dibenzylamino)-1-(5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorophenyl)ethanol
CAS No.:1444767-41-2
Molecular Formula:C₂₈H₃₂FNO₄
Molecular Weight:465.565
Hs Code.:

Synonyms:(S)-2-(dibenzylamino)-1-(5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorophenyl)ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(dibenzylamino)-1-(5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorophenyl)ethanol

Chemical Property:

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Technology Process of (S)-2-(dibenzylamino)-1-(5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorophenyl)ethanol

There total 6 articles about (S)-2-(dibenzylamino)-1-(5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorophenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1444767-40-1
(S)-2-amino-1-(5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorophenyl)ethanol

: 100-39-0
benzyl bromide

: 1444767-41-2
(S)-2-(dibenzylamino)-1-(5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorophenyl)ethanol

Guidance literature:: With potassium carbonate; In ethanol; at 20 ℃;

Reference yield:

: 1444767-39-8
(S)-1-(5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorophenyl)-2-nitroethanol

: 1444767-41-2
(S)-2-(dibenzylamino)-1-(5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorophenyl)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 48 h / 20 °C / 760.05 Torr

2: potassium carbonate / ethanol / 20 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; ethanol;

Reference yield:

: 103438-84-2
methyl 2-amino-3-(2-fluoro-5-hydroxyphenyl)propanoate

: 1444767-41-2
(S)-2-(dibenzylamino)-1-(5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-fluorophenyl)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / dimethyl sulfoxide / 16 h / 70 °C

2: (1R)-1,7,7-trimethyl-N-(pyridin-2-ylmethyl)bicyclo[2.2.1]heptan-2-amine; copper diacetate; N-ethyl-N,N-diisopropylamine / ethanol / 25 h / -40 - 20 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 48 h / 20 °C / 760.05 Torr

4: potassium carbonate / ethanol / 20 °C

With palladium 10% on activated carbon; (1R)-1,7,7-trimethyl-N-(pyridin-2-ylmethyl)bicyclo[2.2.1]heptan-2-amine; hydrogen; copper diacetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dimethyl sulfoxide;