1,4alpha-Diphenyl-3beta-methylazetidin-2-one

Base Information

Chemical Name:1,4alpha-Diphenyl-3beta-methylazetidin-2-one
CAS No.:888482-29-9
Molecular Formula:C₁₆H₁₅NO
Molecular Weight:237.301
Hs Code.:
DSSTox Substance ID:DTXSID001262219
Nikkaji Number:J902.256B

Synonyms:DTXSID001262219;1,4alpha-Diphenyl-3beta-methylazetidin-2-one;(3S,4R)-3-Methyl-1,4-diphenyl-2-azetidinone;888482-29-9

Suppliers and Price of 1,4alpha-Diphenyl-3beta-methylazetidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,4alpha-Diphenyl-3beta-methylazetidin-2-one

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:237.115364102
Heavy Atom Count:18
Complexity:302

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1C(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3
Isomeric SMILES:C[C@H]1[C@@H](N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 1,4alpha-Diphenyl-3beta-methylazetidin-2-one

There total 8 articles about 1,4alpha-Diphenyl-3beta-methylazetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 66977-67-1
(S)-3-methylene-1,4-diphenylazetidin-2-one

: 888482-29-9
(3R,4S)-3-methyl-1,4-diphenylazetidin-2-one

: (3R,4R)-3-methyl-1,4-diphenylazetidin-2-one

Guidance literature:: With 5% Pd/C; hydrogen; In methanol; at 20 ℃; for 12h; under 3800.26 Torr;
DOI:10.1002/anie.201204925

Reference yield:

: 105479-98-9
ethyl 2-(acetoxy(phenyl)methyl)acrylate

: 888482-29-9
(3R,4S)-3-methyl-1,4-diphenylazetidin-2-one

: (3R,4R)-3-methyl-1,4-diphenylazetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: C52H54O2P2; bis(η3-allyl-μ-chloropalladium(II)); potassium carbonate / dichloromethane / 3 h / 20 °C / Inert atmosphere; Schlenk technique

2: bis(bis(trimethylsilyl)amido)tin(II) / toluene / 3 h / Inert atmosphere; Reflux

3: hydrogen; 5% Pd/C / methanol / 12 h / 20 °C / 3800.26 Torr

With bis(η3-allyl-μ-chloropalladium(II)); C₅₂H₅₄O₂P₂; 5% Pd/C; hydrogen; bis(bis(trimethylsilyl)amido)tin(II); potassium carbonate; In methanol; dichloromethane; toluene;
DOI:10.1002/anie.201204925

Reference yield:

: 100-52-7
benzaldehyde

: 888482-29-9
(3R,4S)-3-methyl-1,4-diphenylazetidin-2-one

: (3R,4R)-3-methyl-1,4-diphenylazetidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / neat (no solvent) / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3: bis(η3-allyl-μ-chloropalladium(II)); potassium carbonate; C46H42N2O2 / dichloromethane / 3 h / 20 °C / Inert atmosphere; Schlenk technique

4: bis(bis(trimethylsilyl)amido)tin(II) / toluene / 3 h / Inert atmosphere; Reflux

5: hydrogen; 5% Pd/C / methanol / 12 h / 20 °C / 3800.26 Torr

With 1,4-diaza-bicyclo[2.2.2]octane; bis(η3-allyl-μ-chloropalladium(II)); C₄₆H₄₂N₂O₂; 5% Pd/C; hydrogen; bis(bis(trimethylsilyl)amido)tin(II); potassium carbonate; triethylamine; In methanol; dichloromethane; toluene; 1: |Baylis-Hillman Reaction;
DOI:10.1002/anie.201204925