(R)-2-ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2,6-difluoro-3-hydroxy-benzyl)ester

Base Information

Chemical Name:(R)-2-ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2,6-difluoro-3-hydroxy-benzyl)ester
CAS No.:438050-30-7
Molecular Formula:C₁₉H₂₆F₂N₂O₅
Molecular Weight:400.423
Hs Code.:

Synonyms:(R)-2-ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2,6-difluoro-3-hydroxy-benzyl)ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2,6-difluoro-3-hydroxy-benzyl)ester

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Technology Process of (R)-2-ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2,6-difluoro-3-hydroxy-benzyl)ester

There total 6 articles about (R)-2-ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2,6-difluoro-3-hydroxy-benzyl)ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 438050-10-3
(R)-2-ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(3-bromo-2,6-difluoro-benzyl)ester

: 438050-30-7
(R)-2-ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2,6-difluoro-3-hydroxy-benzyl)ester

Guidance literature:: With n-butyllithium; dihydrogen peroxide; acetic acid; In tetrahydrofuran;

Reference yield:

: 347195-55-5
(R)-1-benzyl-3-ethylpiperazine

: 438050-30-7
(R)-2-ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2,6-difluoro-3-hydroxy-benzyl)ester

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / palladium / ethanol

2: triethylamine / methanol; dichloromethane

3: pyridine / dichloromethane

5: n-butyllithium; dihydrogen peroxide; acetic acid / tetrahydrofuran

With pyridine; hydrogenchloride; n-butyllithium; dihydrogen peroxide; acetic acid; triethylamine; palladium; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 128427-05-4,438050-07-8
(R)-2-ethylpiperazine dihydrochloride

: 438050-30-7
(R)-2-ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2,6-difluoro-3-hydroxy-benzyl)ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / methanol; dichloromethane

2: pyridine / dichloromethane

4: n-butyllithium; dihydrogen peroxide; acetic acid / tetrahydrofuran

With pyridine; n-butyllithium; dihydrogen peroxide; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane;