N-(5-(cyano(5-oxo-3-phenylthiazolidin-2-yl)methyl)-1,3,4-oxadiazol-2-yl)benzamide

Base Information

• Chemical Name: N-(5-(cyano(5-oxo-3-phenylthiazolidin-2-yl)methyl)-1,3,4-oxadiazol-2-yl)benzamide
• CAS No.: 1357598-13-0
• Molecular Formula: C₂₀H₁₃N₅O₃S
• Molecular Weight: 403.421

Synonyms:N-(5-(cyano(5-oxo-3-phenylthiazolidin-2-yl)methyl)-1,3,4-oxadiazol-2-yl)benzamide

Chemical Property of N-(5-(cyano(5-oxo-3-phenylthiazolidin-2-yl)methyl)-1,3,4-oxadiazol-2-yl)benzamide

Chemical Property:

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Technology Process of N-(5-(cyano(5-oxo-3-phenylthiazolidin-2-yl)methyl)-1,3,4-oxadiazol-2-yl)benzamide

There total 1 articles about N-(5-(cyano(5-oxo-3-phenylthiazolidin-2-yl)methyl)-1,3,4-oxadiazol-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyanoacetic acid 2'-[(benzoylamino)thiocarbonyl]hydrazide (54779-96-3) → N-(5-(cyano(5-oxo-3-phenylthiazolidin-2-yl)methyl)-1,3,4-oxadiazol-2-yl)benzamide (1357598-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: mercury(II) oxide / ethanol / 4 h / Reflux

2.1: potassium hydroxide / N,N-dimethyl-formamide / 10 h / 0 - 5 °C

2.2: 4 h

With potassium hydroxide; mercury(II) oxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.12.013

Reference yield: 69.0%

N-(5-(cyano(5-oxo-3-phenylthiazolidin-2-yl)methyl)-1,3,4-oxadiazol-2-yl)benzamide (1357598-13-0) + 1,3-diphenyl-4-formylpyrazole (21487-45-6) → N-(5-(cyano-4-((1,3-diphenyl-1H-pyrazol-4-yl)methylen-5-oxo-3-phenylthiazolidin-2-ylidene)methyl)-1,3,4-oxadiazol-2-yl)benzamide (1357597-89-7)

Guidance literature:

With sodium acetate; acetic acid; for 6h; Heating;

DOI:10.1016/j.ejmech.2011.12.013

Reference yield: 62.0%

4-formyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one (950-81-2) + N-(5-(cyano(5-oxo-3-phenylthiazolidin-2-yl)methyl)-1,3,4-oxadiazol-2-yl)benzamide (1357598-13-0) → N-(5-(cyano-(4-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)methylene)-5-oxo-3-phenylthiazolidin-2-ylidene)methyl)-1,3,4-oxadiazol-2-yl)benzamide (1357597-91-1)

Guidance literature:

With sodium acetate; acetic acid; for 6h; Heating;

DOI:10.1016/j.ejmech.2011.12.013

upstream raw materials:

cyanoacetic acid 2'-[(benzoylamino)thiocarbonyl]hydrazide

Downstream raw materials:

N-(5-(cyano-(4-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)methylene)-5-oxo-3-phenylthiazolidin-2-ylidene)methyl)-1,3,4-oxadiazol-2-yl)benzamide

N-(5-(cyano-4-((1,3-diphenyl-1H-pyrazol-4-yl)methylen-5-oxo-3-phenylthiazolidin-2-ylidene)methyl)-1,3,4-oxadiazol-2-yl)benzamide

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