(R)-5-benzyl-1-[(R)-2-hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-1H-pyrrol-2(5H)-one

Base Information

Chemical Name:(R)-5-benzyl-1-[(R)-2-hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-1H-pyrrol-2(5H)-one
CAS No.:1268345-02-3
Molecular Formula:C₂₁H₂₃NO₄
Molecular Weight:353.418
Hs Code.:

Synonyms:(R)-5-benzyl-1-[(R)-2-hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-1H-pyrrol-2(5H)-one

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Chemical Property of (R)-5-benzyl-1-[(R)-2-hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-1H-pyrrol-2(5H)-one

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Technology Process of (R)-5-benzyl-1-[(R)-2-hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-1H-pyrrol-2(5H)-one

There total 6 articles about (R)-5-benzyl-1-[(R)-2-hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-1H-pyrrol-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110104-60-4,85153-60-2
(E)-4-chloro-3-methoxy-but-2-enoic acid methyl ester

: 1268345-02-3
(R)-5-benzyl-1-[(R)-2-hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetonitrile / 0.25 h / 80 °C

1.2: 7 h / 80 °C

2.1: tert.-butyl lithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 7 h / -78 °C

With tert.-butyl lithium; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1002/chem.201002063

Reference yield:

: 1268345-14-7
methyl (R)-2-[(methoxycarbonyl)amino]-2-(4-methoxyphenyl) acetate

: 1268345-02-3
(R)-5-benzyl-1-[(R)-2-hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-1H-pyrrol-2(5H)-one

: 1268345-03-4
(S)-5-benzyl-1-[(R)-2-hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-1H-pyrrol-2(5H)-one

: 1268345-04-5
3-benzyl-1-[(R)-2-hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / -20 - 0 °C / Inert atmosphere

2.1: water; potassium hydroxide / 50 °C

3.1: acetonitrile / 0.25 h / 80 °C

3.2: 7 h / 80 °C

4.1: tert.-butyl lithium / tetrahydrofuran; hexane / 1 h / -78 °C

4.2: 7 h / -78 °C

With lithium aluminium tetrahydride; water; tert.-butyl lithium; potassium hydroxide; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1002/chem.201002063

Reference yield:

: 1268345-15-8
(R)-2-[(methoxycarbonyl)amino]-2-(4-methoxyphenyl)-1-ethanol

: 1268345-02-3
(R)-5-benzyl-1-[(R)-2-hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-1H-pyrrol-2(5H)-one

: 1268345-03-4
(S)-5-benzyl-1-[(R)-2-hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-1H-pyrrol-2(5H)-one

: 1268345-04-5
3-benzyl-1-[(R)-2-hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; potassium hydroxide / 50 °C

2.1: acetonitrile / 0.25 h / 80 °C

2.2: 7 h / 80 °C

3.1: tert.-butyl lithium / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 7 h / -78 °C

With water; tert.-butyl lithium; potassium hydroxide; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1002/chem.201002063