[2-Fluoro-4-(methylsulfonyl)phenyl]hydrazine

Base Information

• Chemical Name: [2-Fluoro-4-(methylsulfonyl)phenyl]hydrazine
• CAS No.: 832714-48-4
• Molecular Formula: C₇H₉FN₂O₂S
• Molecular Weight: 204.225
• Hs Code.: 2928000090
• European Community (EC) Number: 674-408-8
• DSSTox Substance ID: DTXSID80382255
• Wikidata: Q82173567
• Mol file: 832714-48-4.mol

Synonyms:832714-48-4;[2-fluoro-4-(methylsulfonyl)phenyl]hydrazine;(2-Fluoro-4-(methylsulfonyl)phenyl)hydrazine;(2-fluoro-4-methylsulfonylphenyl)hydrazine;2-fluoro-4-(methylsulphonyl)phenylhydrazine;(2-fluoro-4-methanesulfonylphenyl)hydrazine;(2-Fluoro-4-methanesulfonyl-phenyl)-hydrazine;SCHEMBL1243294;DTXSID80382255;IOOKDEPCDHCNSK-UHFFFAOYSA-N;MFCD04037953;AKOS015854346;AS-8958;2-fluoro-4-methylsulfonylphenyl hydrazine;CS-0314529;FT-0676976;[2-Fluoro-4-(methanesulfonyl)phenyl]hydrazine;1-fluoro-1-(4-methylsulfonylphenyl)hydrazine;A840549;J-502734

Chemical Property of [2-Fluoro-4-(methylsulfonyl)phenyl]hydrazine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 102-104
• Refractive Index: 1.585
• Boiling Point: 383.142°C at 760 mmHg
• Flash Point: 185.518°C
• PSA: 80.57000
• Density: 1.438g/cm³
• LogP: 2.36890
• Storage Temp.: 2-8°C
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 204.03687687
• Heavy Atom Count: 13
• Complexity: 262

Purity/Quality:

97% ^*data from raw suppliers

[2-Fluoro-4-(methylsulfonyl)phenyl]hydrazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CS(=O)(=O)C1=CC(=C(C=C1)NN)F

Technology Process of [2-Fluoro-4-(methylsulfonyl)phenyl]hydrazine

There total 1 articles about [2-Fluoro-4-(methylsulfonyl)phenyl]hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1,2-difluoro-4-(methylsulfonyl)benzene (424792-57-4) → (2-fluoro-4-(methylsulfonyl)phenyl)hydrazine (832714-48-4)

Guidance literature:

With hydrazine; In isopropyl methanesulfonate; at 0 ℃; Heating / reflux;

Reference yield:

(2-fluoro-4-(methylsulfonyl)phenyl)hydrazine (832714-48-4) → N5-((2-fluoro-4-(methylsulfonyl)phenyl)amino)-L-glutamine

Guidance literature:

Multi-step reaction with 2 steps

1: O‐(1H‐benzotriazol‐1‐yl)‐N,N,N′,N′‐tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / -25 - 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; O‐(1H‐benzotriazol‐1‐yl)‐N,N,N′,N′‐tetramethyluronium tetrafluoroborate; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2017.11.012

Reference yield:

(2-fluoro-4-(methylsulfonyl)phenyl)hydrazine (832714-48-4) → 1-(2-fluoro-4-methanesulfonyl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one (832714-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / Reflux

2: water / Reflux

In methanol; water;

DOI:10.1016/j.bmcl.2011.03.007

upstream raw materials:

1,2-difluoro-4-(methylsulfonyl)benzene

Downstream raw materials:

1-(2-fluoro-4-methanesulfonyl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

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