424792-57-4

Basic information

• Product Name: 1,2-DIFLUORO-4-(METHYLSULFONYL)BENZENE
• Synonyms: 1,2-Difluoro-4-(methylsulphonyl)benzene;3,4-Difluorophenyl methyl sulphone;3,4-Difluorophenyl Methyl Sulfone;EOS-60469;1,2-difluoro-4-methanesulfonyl-benzene
• CAS NO: 424792-57-4
• Molecular Formula: C₇H₆F₂O₂S
• Molecular Weight: 192.18
• Product Categories: blocks;BuildingBlocks;FluoroCompounds
• Mol File: 424792-57-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 71°C
• Boiling Point: 302.4 °C at 760 mmHg
• Flash Point: 136.7 °C
• Appearance: /
• Density: 1.376 g/cm³
• Vapor Pressure: 0.00178mmHg at 25°C
• Refractive Index: 1.49
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: 1,2-DIFLUORO-4-(METHYLSULFONYL)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DIFLUORO-4-(METHYLSULFONYL)BENZENE(424792-57-4)
• EPA Substance Registry System: 1,2-DIFLUORO-4-(METHYLSULFONYL)BENZENE(424792-57-4)

Safety Data

• Hazardous Substances Data: 424792-57-4(Hazardous Substances Data)

Usage

Uses

1,2-Difluoro-4-methylsulfonylbenzene

InChI:InChI=1/C7H6F2O2S/c1-12(10,11)5-2-3-6(8)7(9)4-5/h2-4H,1H3

Upstream product

• 75-75-2 methanesulfonic acid 
• 367-11-3 ortho-difluorobenzene 
• 130922-41-7 (3,4-difluorophenyl)(methyl)sulfane 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 929212-99-7 bis(2-fluoro-4-methanesulfonyl-benzene)disulfide 
• 1184745-98-9 (S)-isopropyl6-(1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidin-3-yloxy)-3,4-dihydroisoquinorine-2(1H)-carboxylate 
• 1184746-22-2 (S)-3-(1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidin-3-yloxy)benzyl isopropyl carbonate 
• 1184746-23-3 C₁₈H₂₀FNO₄S 
• 1054520-98-7 (S)-3-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-5-(1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidin-3-yl)-1,2,4-oxadiazole 
• 1054520-94-3 (S)-tert-butyl 4-(5-(1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidin-3-yl)-1,2,4-oxadiazol-3-yl)piperidine-1-carboxylate 
• 1054521-18-4 (S)-isopropyl 4-(2-(1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidin-3-yl)-2H-tetrazol-5-yl)piperidine-1-carboxylat 
• 1054521-10-6 (S)-isopropyl 4-(4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidin-3-yl)oxazol-2-yl)piperidine-1-carboxylate 
• 1054521-12-8 (S)-isopropyl 4-(4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidin-3-yl)thiazol-2-yl)piperidine-1-carboxylate 
• 1054521-92-4 C₁₇H₂₃FN₆O₂S 
• 1054521-46-8 C₁₃H₁₅ClFNO₃S 
• 1054521-32-2 (R)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidin-3-ol methanesulfonate 
• 1054521-34-4 (S)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidine-3-carbonitrile 
• 1339944-38-5 tert-butyl 4-(5-chloro-1-(2-fluoro-4-(methylsulfonyl)-phenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate 

Relevant articles and documents

GPR119 Receptor Agonists

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.

SYNTHESIS OF METHYLSULPHONYL BENZENE COMPOUNDS

The present invention relates to a process for the synthesis of l-substituted-2-fluoro-4- methylsulfonylphenyl compounds.

BENZAMIDE DERIVATIVES THAT ACT UPON THE GLUCOKINASE ENZYME

Compounds of Formula: (I); wherein: R1 is hydroxymethyl; R2 is selected from -C(O)NR4R5, SO2NR4R5, S(O)pR4 and HET-2; HET-1 is a 5- or 6-membered, optionally substitut