(+)-methyl (S)-α-acetoxyphenylacetate

Base Information

• Chemical Name: (+)-methyl (S)-α-acetoxyphenylacetate
• CAS No.: 79416-45-8
• Molecular Formula: C₁₁H₁₂O₄
• Molecular Weight: 208.214
• Mol file: 79416-45-8.mol

Synonyms:(+)-methyl (S)-α-acetoxyphenylacetate

Chemical Property of (+)-methyl (S)-α-acetoxyphenylacetate

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-methyl (S)-α-acetoxyphenylacetate

There total 42 articles about (+)-methyl (S)-α-acetoxyphenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(S)-Methyl mandelate (21210-43-5) + acetic anhydride (108-24-7) → (+)-methyl (S)-α-acetoxyphenylacetate (79416-45-8)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In dichloromethane; for 1h; Ambient temperature;

DOI:10.1016/S0040-4039(99)00229-4

Reference yield: 90.0%

(S)-Methyl mandelate (21210-43-5) + propionic acid (802294-64-0,79-09-4) → (+)-methyl (S)-α-acetoxyphenylacetate (79416-45-8)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at -10 ℃; for 3h;

DOI:10.1039/P29830000083

Reference yield: 47.0%

methyl O-acetylmandalate (86561-27-5) → (S)-Methyl mandelate (21210-43-5) + (+)-methyl (S)-α-acetoxyphenylacetate (79416-45-8) + methyl (R)-(-)-2-acetyloxy-2-phenylacetate (947-94-4,79416-45-8,86561-27-5,82078-97-5)

Guidance literature:

With AmanoPS lipase; water; In Petroleum ether; benzene; at 25 ℃; for 144h; Yields of byproduct given; pH 7.0 (aq. sodium phosphate buffer); further solvents and period of time;

upstream raw materials:

(S)-acetylmandelic acid

vinyl acetate

(RS)-methyl mandelate

(S)-Methyl mandelate

Downstream raw materials:

(S)-Methyl mandelate

Refernces

• 1、 Nishihara,Shiomi,Kadotani,Nokami,Itoh. "Remarkably improved stability and enhanced activity of a: Burkholderia cepacia lipase by coating with a triazolium alkyl-PEG sulfate ionic liquid". supporting information. p. 5250 - 5256. Retrieved 2017/11/09.
• 2、 Peng, Ruixue,Lin, Lili,Zhang, Yuheng,Wu, Wangbin,Lu, Yan,Liu, Xiaohua,Feng, Xiaoming. "The assignment of the configuration for α-hydroxy acid esters using a CEC strategy". . p. 5258 - 5262. Retrieved 2016/07/06.