(2R,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-biphenyl-4-yl-2-hydroxypentanoic acid ethyl ester trifluoroacetate

Base Information

Chemical Name:(2R,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-biphenyl-4-yl-2-hydroxypentanoic acid ethyl ester trifluoroacetate
CAS No.:1383005-20-6
Molecular Formula:C₂HF₃O₂*C₂₅H₂₇N₃O₅
Molecular Weight:563.53
Hs Code.:

Synonyms:(2R,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-biphenyl-4-yl-2-hydroxypentanoic acid ethyl ester trifluoroacetate

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Chemical Property of (2R,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-biphenyl-4-yl-2-hydroxypentanoic acid ethyl ester trifluoroacetate

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Technology Process of (2R,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-biphenyl-4-yl-2-hydroxypentanoic acid ethyl ester trifluoroacetate

There total 11 articles about (2R,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-biphenyl-4-yl-2-hydroxypentanoic acid ethyl ester trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-acetyl-1H-pyrazole-5-carboxylic acid

: (2R,4R)-4-amino-5-biphenyl-4-yl-2-hydroxypentanoic acid ethyl ester hydrochloride

: 1383005-20-6
(2R,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-biphenyl-4-yl-2-hydroxypentanoic acid ethyl ester trifluoroacetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 1h;

Reference yield:

: 3-acetyl-1H-pyrazole-5-carboxylic acid

: (2R,4R)-4-amino-5-biphenyl-4-yl-2-hydroxypentanoic acid ethyl ester hydrochloride

: 76-05-1
trifluoroacetic acid

: 1383005-20-6
(2R,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-biphenyl-4-yl-2-hydroxypentanoic acid ethyl ester trifluoroacetate

Guidance literature:: 3-acetyl-1H-pyrazole-5-carboxylic acid; (2R,4R)-4-amino-5-biphenyl-4-yl-2-hydroxypentanoic acid ethyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 1h;

trifluoroacetic acid;

Reference yield:

: 1038924-77-4
(S)-2-biphenyl-4-ylmethyl-5-oxopyrrolidine-1-carboxylic acid tert-butyl ester

: 1383005-20-6
(2R,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-biphenyl-4-yl-2-hydroxypentanoic acid ethyl ester trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C

2.2: 1 h / -78 °C

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

3.2: 0.5 h

4.1: hydrogenchloride / water / 20 h / 90 - 95 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

With hydrogenchloride; n-butyllithium; sodium hexamethyldisilazane; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; hexanes; water; ethyl acetate; N,N-dimethyl-formamide;