(S)-5-[(Biphenyl-4-yl)methyl]-1-(2,2-dimethylpropionyl)pyrrolidin-2-one

Base Information

Chemical Name:(S)-5-[(Biphenyl-4-yl)methyl]-1-(2,2-dimethylpropionyl)pyrrolidin-2-one
CAS No.:1038924-65-0
Molecular Formula:C22H25NO2
Molecular Weight:335.446
Hs Code.:
Mol file:1038924-65-0.mol

Synonyms:(S)-5-[(Biphenyl-4-yl)methyl]-1-(2,2-dimethylpropionyl)pyrrolidin-2-one;LCZ696 intermediate D

Suppliers and Price of (S)-5-[(Biphenyl-4-yl)methyl]-1-(2,2-dimethylpropionyl)pyrrolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
(S)-5-([1,1''-biphenyl]-4-ylmethyl)-1-pivaloylpyrrolidin-2-one 97%
10g
$ 580.00

Chemenu
(S)-5-([1,1''-biphenyl]-4-ylmethyl)-1-pivaloylpyrrolidin-2-one 97%
5g
$ 337.00

Alichem
(S)-5-([1,1'-Biphenyl]-4-ylmethyl)-1-pivaloylpyrrolidin-2-one
10g
$ 620.00

Total 25 raw suppliers

Chemical Property of (S)-5-[(Biphenyl-4-yl)methyl]-1-(2,2-dimethylpropionyl)pyrrolidin-2-one

Chemical Property:

Boiling Point:498.7±24.0 °C(Predicted)
PKA:-1.58±0.40(Predicted)
PSA：37.38000
Density:1.115±0.06 g/cm3(Predicted)
LogP:4.39770

Purity/Quality:

97% ^*data from raw suppliers

(S)-5-([1,1''-biphenyl]-4-ylmethyl)-1-pivaloylpyrrolidin-2-one 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (S)-5-[(Biphenyl-4-yl)methyl]-1-(2,2-dimethylpropionyl)pyrrolidin-2-one

There total 5 articles about (S)-5-[(Biphenyl-4-yl)methyl]-1-(2,2-dimethylpropionyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1038924-61-6
(S)-5-biphenyl-4-ylmethylpyrrolidin-2-one

: 3282-30-2
pivaloyl chloride

: 1038924-65-0
(S)-5-biphenyl-4-ylmethyl-1-(2,2-dimethyl-propionyl)-pyrrolidin-2-one

Guidance literature:: (S)-5-biphenyl-4-ylmethylpyrrolidin-2-one; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

pivaloyl chloride; In tetrahydrofuran; for 1h; Product distribution / selectivity;

Reference yield:

: 1038924-77-4
(S)-2-biphenyl-4-ylmethyl-5-oxopyrrolidine-1-carboxylic acid tert-butyl ester

: 1038924-65-0
(S)-5-biphenyl-4-ylmethyl-1-(2,2-dimethyl-propionyl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C

2.2: 1 h / -78 °C

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; hexanes; ethyl acetate;

Reference yield:

: 128779-47-5
(2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

: 1038924-65-0
(S)-5-biphenyl-4-ylmethyl-1-(2,2-dimethyl-propionyl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / -5 °C / Inert atmosphere

2.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere

2.2: 3 h / -5 °C

3.1: toluene / 3 h / Inert atmosphere; Reflux

4.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

5.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C

5.2: 1 h / -78 °C

With hydrogenchloride; dmap; n-butyllithium; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexanes; dichloromethane; ethyl acetate; toluene;