Oxiranemethanol,2-(2,5-difluorophenyl)--alpha--methyl-,(-alpha-R,2R)-(9CI)

Base Information

Chemical Name:Oxiranemethanol,2-(2,5-difluorophenyl)--alpha--methyl-,(-alpha-R,2R)-(9CI)
CAS No.:832152-04-2
Molecular Formula:C10H10 F2 O2
Molecular Weight:200.18
Hs Code.:
Mol file:832152-04-2.mol

Synonyms:Oxiranemethanol,2-(2,5-difluorophenyl)-a-methyl-, (aR,2R)-(9CI)

Suppliers and Price of Oxiranemethanol,2-(2,5-difluorophenyl)--alpha--methyl-,(-alpha-R,2R)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Oxiranemethanol,2-(2,5-difluorophenyl)--alpha--methyl-,(-alpha-R,2R)-(9CI)

Chemical Property:

Boiling Point:281.2±40.0 °C(Predicted)
PKA:14.51±0.20(Predicted)
PSA：32.76000
Density:1.348±0.06 g/cm3(Predicted)
LogP:1.57110

Purity/Quality:: 99%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Oxiranemethanol,2-(2,5-difluorophenyl)--alpha--methyl-,(-alpha-R,2R)-(9CI)

There total 3 articles about Oxiranemethanol,2-(2,5-difluorophenyl)--alpha--methyl-,(-alpha-R,2R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 832152-04-2
(2R,3R)-3-(2,5-difluorophenyl)-3,4-epoxy-2-butanol

Guidance literature:: With tartaric acid; In tetrahydrofuran; water; dimethyl sulfoxide; toluene; at 5 - 10 ℃; pH=2.1;

With sodium hydrogencarbonate; In tetrahydrofuran; water; dimethyl sulfoxide; toluene; at 20 ℃; pH=8.5; Purification / work up;

Reference yield:

: (2R,3R)-1-chloro-2-(2,5-difluorophenyl)-3-pivaloyloxybutan-2-ol

: (2S,3R)-1-chloro-2-(2,5-difluorophenyl)-3-pivaloyloxybutan-2-ol

: 832152-04-2
(2R,3R)-3-(2,5-difluorophenyl)-3,4-epoxy-2-butanol

: (2S,3R)-1,2-epoxy-2-(2,5-difluorophenyl)butan-3-ol

Guidance literature:: (2R,3R)-1-chloro-2-(2,5-difluorophenyl)-3-pivaloyloxybutan-2-ol; (2S,3R)-1-chloro-2-(2,5-difluorophenyl)-3-pivaloyloxybutan-2-ol; With sodium methylate; In tetrahydrofuran; methanol; at 0 ℃; for 5h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

: (R)-1-(2,5-difluorophenyl)-2-hydroxy-1-propanone

: 25596-24-1
trimethyloxosulfonium bromide

: 832152-04-2
(2R,3R)-3-(2,5-difluorophenyl)-3,4-epoxy-2-butanol

: 1-(2,5-difluorophenyl)-1-(2-methyl-2-oxiranyl)methanol

Guidance literature:: trimethyloxosulfonium bromide; With sodium hydride; In tetrahydrofuran; paraffin oil; mineral oil; at 50 ℃;

(R)-1-(2,5-difluorophenyl)-2-hydroxy-1-propanone; In tetrahydrofuran; toluene; paraffin oil; mineral oil; at 0 ℃; for 5h; Overall yield = 81.1 percent; Overall yield = 15.26 g;