(S,S,S)-1-(2'-methylphenanthridinyl)-4,7,10-tris[1-(1-phenyl)ethylcarbamoylmethyl]-1,4,7,10-tetraazacyclododecane

Base Information

• Chemical Name: (S,S,S)-1-(2'-methylphenanthridinyl)-4,7,10-tris[1-(1-phenyl)ethylcarbamoylmethyl]-1,4,7,10-tetraazacyclododecane
• CAS No.: 308821-51-4
• Molecular Formula: C₅₂H₆₂N₈O₃
• Molecular Weight: 847.116

Synonyms:(S,S,S)-1-(2'-methylphenanthridinyl)-4,7,10-tris[1-(1-phenyl)ethylcarbamoylmethyl]-1,4,7,10-tetraazacyclododecane

Chemical Property of (S,S,S)-1-(2'-methylphenanthridinyl)-4,7,10-tris[1-(1-phenyl)ethylcarbamoylmethyl]-1,4,7,10-tetraazacyclododecane

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of (S,S,S)-1-(2'-methylphenanthridinyl)-4,7,10-tris[1-(1-phenyl)ethylcarbamoylmethyl]-1,4,7,10-tetraazacyclododecane

There total 3 articles about (S,S,S)-1-(2'-methylphenanthridinyl)-4,7,10-tris[1-(1-phenyl)ethylcarbamoylmethyl]-1,4,7,10-tetraazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

2-chloro-N-((1S)-1-phenylethyl)acetamide (36293-01-3) + 1-(2'-methylphenanthridinyl)-1,4,7,10-tetraazacyclododecane (308821-47-8) → (S,S,S)-1-(2'-methylphenanthridinyl)-4,7,10-tris[1-(1-phenyl)ethylcarbamoylmethyl]-1,4,7,10-tetraazacyclododecane (308821-51-4)

Guidance literature:

With caesium carbonate; In dichloromethane; acetonitrile; at 80 ℃;

DOI:10.1021/ja001797x

Reference yield:

3’-methylphenanthridine (23002-14-4) → (S,S,S)-1-(2'-methylphenanthridinyl)-4,7,10-tris[1-(1-phenyl)ethylcarbamoylmethyl]-1,4,7,10-tetraazacyclododecane (308821-51-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent Spectr_. / NBS; AIBN / CCl₄ / 1.5 h / 60 °C

2: Cs₂CO₃ / acetonitrile / 0.75 h / 80 °C

3: 43 percent / Cs₂CO₃ / acetonitrile; CH₂Cl₂ / 80 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); caesium carbonate; In tetrachloromethane; dichloromethane; acetonitrile;

DOI:10.1021/ja001797x

Reference yield:

2-bromomethylphenanthridine → (S,S,S)-1-(2'-methylphenanthridinyl)-4,7,10-tris[1-(1-phenyl)ethylcarbamoylmethyl]-1,4,7,10-tetraazacyclododecane (308821-51-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Cs₂CO₃ / acetonitrile / 0.75 h / 80 °C

2: 43 percent / Cs₂CO₃ / acetonitrile; CH₂Cl₂ / 80 °C

With caesium carbonate; In dichloromethane; acetonitrile;

DOI:10.1021/ja001797x

upstream raw materials:

2-chloro-N-((1S)-1-phenylethyl)acetamide

1-(2'-methylphenanthridinyl)-1,4,7,10-tetraazacyclododecane

3’-methylphenanthridine

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