(2S,4R)-N-(benzyloxycarbonyl)-4-acetoxyproline

Base Information

Chemical Name:(2S,4R)-N-(benzyloxycarbonyl)-4-acetoxyproline
CAS No.:89625-39-8
Molecular Formula:C₁₅H₁₇NO₆
Molecular Weight:307.303
Hs Code.:

Synonyms:(2S,4R)-N-(benzyloxycarbonyl)-4-acetoxyproline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4R)-N-(benzyloxycarbonyl)-4-acetoxyproline

Chemical Property:

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Technology Process of (2S,4R)-N-(benzyloxycarbonyl)-4-acetoxyproline

There total 2 articles about (2S,4R)-N-(benzyloxycarbonyl)-4-acetoxyproline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 108-24-7
acetic anhydride

: 501-53-1,94274-21-2
benzyl chloroformate

: 51-35-4,30724-02-8
4R-4-hydroxyproline

: 89625-39-8
(2S,4R)-N-(benzyloxycarbonyl)-4-acetoxyproline

Guidance literature:: benzyl chloroformate; 4R-4-hydroxyproline; With sodium hydrogencarbonate; In tetrahydrofuran; water; at 0 - 26 ℃; Inert atmosphere;

acetic anhydride; With pyridine; In dichloromethane; at 26 ℃; Inert atmosphere;
DOI:10.1039/c7ob02033c

Reference yield: 51.0%

: 108-24-7
acetic anhydride

: 13504-85-3
(2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

: 89625-39-8
(2S,4R)-N-(benzyloxycarbonyl)-4-acetoxyproline

Guidance literature:: With pyridine; dmap; In dichloromethane; at 20 ℃; for 19h;
DOI:10.1002/ejoc.200901283

Reference yield: 94.0%

: 89625-39-8
(2S,4R)-N-(benzyloxycarbonyl)-4-acetoxyproline

: 89625-49-0
C₁₅H₁₉NO₅

Guidance literature:: With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 20 ℃; for 20h; Inert atmosphere;
DOI:10.1002/ejoc.200901283