Tipifarnib (S enantioMer)

Base Information

• Chemical Name: Tipifarnib (S enantioMer)
• CAS No.: 192185-71-0
• Molecular Formula: C₂₇H₂₂Cl₂N₄O
• Molecular Weight: 489.404
• Mol file: 192185-71-0.mol

Synonyms:tiparfinib

Chemical Property of Tipifarnib (S enantioMer)

Chemical Property:

• Boiling Point: 681.7±55.0 °C(Predicted)
• PKA: 7.20±0.10(Predicted)
• Density: 1.33±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

TipifarnibSenantiomer >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Tipifarnib (S enantioMer)

There total 3 articles about Tipifarnib (S enantioMer) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(S)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1H-quinolin-2-one (869217-40-3) + methyl iodide (74-88-4) → tiparfinib (192185-71-0,192185-72-1)

Guidance literature:

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In tetrahydrofuran; water; at 20 ℃; for 2h;

Reference yield:

N-[(4-chlorophenyl)((4-(3-chlorophenyl)-1-methyl-1H-quinoline-2-one)-6-yl)(1-methyl-1H-imidazole-5-yl)methyl]-2-methyl-2-propanesulfinamide [S(R)] → tiparfinib (192185-71-0,192185-72-1) + tipifarnib (192185-72-1)

Guidance literature:

N-[(4-chlorophenyl)((4-(3-chlorophenyl)-1-methyl-1H-quinoline-2-one)-6-yl)(1-methyl-1H-imidazole-5-yl)methyl]-2-methyl-2-propanesulfinamide [S(R)]; With hydrogenchloride; methanol; water; isopropyl alcohol; at 20 ℃; for 0.5h;

With potassium carbonate; In methanol; water; isopropyl alcohol; at 0 ℃;

Reference yield:

6-[((S)-1-(4-methoxyphenyl)ethylamino)(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)]methyl-4-(3-chlorophenyl)-1-methyl-1H-quinolin-2-one → tiparfinib (192185-71-0,192185-72-1) + tipifarnib (192185-72-1)

Guidance literature:

6-[((S)-1-(4-methoxyphenyl)ethylamino)(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)]methyl-4-(3-chlorophenyl)-1-methyl-1H-quinolin-2-one; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 0.583333h;

With potassium carbonate; In dichloromethane; water; at 0 ℃;

upstream raw materials:

(S)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1H-quinolin-2-one

methyl iodide

Downstream raw materials:

4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-1-methyl-2(1H)-quinolinone