4-[(3-chloro-2-fluoro-phenyl)amino]-6-(1,4-dioxa-spiro[4.5]decan-8-yl-oxy)-7-methoxy-quinazoline

Base Information

Chemical Name:4-[(3-chloro-2-fluoro-phenyl)amino]-6-(1,4-dioxa-spiro[4.5]decan-8-yl-oxy)-7-methoxy-quinazoline
CAS No.:1046137-43-2
Molecular Formula:C₂₃H₂₃ClFN₃O₄
Molecular Weight:459.905
Hs Code.:

Synonyms:4-[(3-chloro-2-fluoro-phenyl)amino]-6-(1,4-dioxa-spiro[4.5]decan-8-yl-oxy)-7-methoxy-quinazoline

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Chemical Property of 4-[(3-chloro-2-fluoro-phenyl)amino]-6-(1,4-dioxa-spiro[4.5]decan-8-yl-oxy)-7-methoxy-quinazoline

Chemical Property:

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Technology Process of 4-[(3-chloro-2-fluoro-phenyl)amino]-6-(1,4-dioxa-spiro[4.5]decan-8-yl-oxy)-7-methoxy-quinazoline

There total 1 articles about 4-[(3-chloro-2-fluoro-phenyl)amino]-6-(1,4-dioxa-spiro[4.5]decan-8-yl-oxy)-7-methoxy-quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 612501-52-7
4-(3-chloro-2-fluoroanilino)-6-hydroxy-7-methoxyquinazoline

: 141120-33-4
8-methylsulfonyloxy-1,4-dioxaspiro[4.5]decane

: 1046137-43-2
4-[(3-chloro-2-fluoro-phenyl)amino]-6-(1,4-dioxa-spiro[4.5]decan-8-yl-oxy)-7-methoxy-quinazoline

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 - 80 ℃;

Reference yield: 90.0%

: 1046137-43-2
4-[(3-chloro-2-fluoro-phenyl)amino]-6-(1,4-dioxa-spiro[4.5]decan-8-yl-oxy)-7-methoxy-quinazoline

: 1046137-42-1
4-[(3-chloro-2-fluoro-phenyl)amino]-6-(4-oxo-cyclohexyloxy)-7-methoxy-quinazoline

Guidance literature:: 4-[(3-chloro-2-fluoro-phenyl)amino]-6-(1,4-dioxa-spiro[4.5]decan-8-yl-oxy)-7-methoxy-quinazoline; With sulfuric acid; In tetrahydrofuran; at 20 ℃;

With sodium hydroxide; In tetrahydrofuran; Product distribution / selectivity;

Reference yield:

: 1046137-43-2
4-[(3-chloro-2-fluoro-phenyl)amino]-6-(1,4-dioxa-spiro[4.5]decan-8-yl-oxy)-7-methoxy-quinazoline

: 4-[(3-chloro-2-fluoro-phenyl)amino]-6-(cis-4-hydroxy-cyclohexyloxy)-7-methoxy-quinazoline

: 4-[(3-chloro-2-fluoro-phenyl)amino]-6-[trans-4-(4-ethyl-3-oxo-piperazin-1-yl)-cyclohexyloxy]-7-methoxy-quinazoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / tetrahydrofuran / 18 h / 20 °C

2.1: acetic acid / dichloromethane / 0.25 h / 20 °C

2.2: 21 h / 20 °C

With sulfuric acid; acetic acid; In tetrahydrofuran; dichloromethane;