3-{4-[(4-cyano-1-naphthyl)oxy]phenyl}-3-ethoxy propionic acid

Base Information

Chemical Name:3-{4-[(4-cyano-1-naphthyl)oxy]phenyl}-3-ethoxy propionic acid
CAS No.:1202575-39-0
Molecular Formula:C₂₂H₁₉NO₄
Molecular Weight:361.397
Hs Code.:

Synonyms:3-{4-[(4-cyano-1-naphthyl)oxy]phenyl}-3-ethoxy propionic acid

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Chemical Property of 3-{4-[(4-cyano-1-naphthyl)oxy]phenyl}-3-ethoxy propionic acid

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Technology Process of 3-{4-[(4-cyano-1-naphthyl)oxy]phenyl}-3-ethoxy propionic acid

There total 5 articles about 3-{4-[(4-cyano-1-naphthyl)oxy]phenyl}-3-ethoxy propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1202577-04-5
ethyl 3-{4-[(4-cyano-1-naphthyl)oxy]phenyl}-3-ethoxy propionate

: 1202575-39-0
3-{4-[(4-cyano-1-naphthyl)oxy]phenyl}-3-ethoxy propionic acid

Guidance literature:: ethyl 3-{4-[(4-cyano-1-naphthyl)oxy]phenyl}-3-ethoxy propionate; With water; sodium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 18h;

With hydrogenchloride; In water;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1202575-39-0
3-{4-[(4-cyano-1-naphthyl)oxy]phenyl}-3-ethoxy propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl acetamide / 20 - 120 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C

3.1: silver(l) oxide / toluene / 20 - 100 °C / Inert atmosphere

4.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 18 h / 20 °C

With water; caesium carbonate; sodium hydroxide; silver(l) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; N,N-dimethyl acetamide; toluene;

Reference yield:

: 13916-99-9
4-fluoronaphthalene-1-carbonitrile

: 1202575-39-0
3-{4-[(4-cyano-1-naphthyl)oxy]phenyl}-3-ethoxy propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl acetamide / 20 - 120 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C

3.1: silver(l) oxide / toluene / 20 - 100 °C / Inert atmosphere

4.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 18 h / 20 °C

With water; caesium carbonate; sodium hydroxide; silver(l) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; N,N-dimethyl acetamide; toluene;