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13916-99-9 Usage

General Description

1-Cyano-4-fluoronaphthalene is a chemical compound with the formula C_12H_7N. It is a naphthalene derivative with a cyano group (-CN) and a fluorine atom attached to the naphthalene ring. 1-CYANO-4-FLUORONAPHTHALENE is a yellowish solid and is commonly used as a building block in the synthesis of various organic compounds. It has potential applications in the pharmaceutical industry, as a precursor for the production of dyes and pigments, and as a fluorescent probe in biological imaging. 1-Cyano-4-fluoronaphthalene is also used in research and development processes to create new materials and substances with specific properties. However, it is important to handle this chemical with care due to its potentially hazardous properties.

Check Digit Verification of cas no

The CAS Registry Mumber 13916-99-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,9,1 and 6 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 13916-99:
119 % 10 = 9
So 13916-99-9 is a valid CAS Registry Number.

13916-99-9 Well-known Company Product Price

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  • Alfa Aesar

  • (B25335)  4-Fluoronaphthalene-1-carbonitrile, 97%   

  • 13916-99-9

  • 1g

  • 542.0CNY

  • Detail
  • Alfa Aesar

  • (B25335)  4-Fluoronaphthalene-1-carbonitrile, 97%   

  • 13916-99-9

  • 5g

  • 1667.0CNY

  • Detail
  • Alfa Aesar

  • (B25335)  4-Fluoronaphthalene-1-carbonitrile, 97%   

  • 13916-99-9

  • 25g

  • 5156.0CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017


1.1 GHS Product identifier


1.2 Other means of identification

Product number -
Other names 4-fluoronaphthalene-1-carbonitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13916-99-9 SDS

13916-99-9Relevant articles and documents


, p. 1777 (1973)

Discovery of flexible naphthyltriazolylmethane-based thioacetic acids as highly active uric acid transporter 1 (URAT1) inhibitors for the treatment of hyperuricemia of gout

Zhang, Xiansheng,Wu, Jingwei,Liu, Wei,Liu, Yuqiang,Xie, Yafei,Shang, Qian,Zhou, Zhixing,Xu, Weiren,Tang, Lida,Wang, Jianwu,Zhao, Guilong

, p. 260 - 281 (2017/05/31)

Background: Gout is the most common inflammatory arthritis, which, if left untreated or inadequately treated, will lead to joint destruction, bone erosion and disability due to the crystal deposition. Uric acid transporter 1 (URAT1) was the promising therapeutic target for urate-lowering therapy. Objective: The goal of this work is to understand the structure-activity relationship (SAR) of a potent lesinurad-based hit, sodium 2-((5-bromo-4-((4-cyclopropyl-naphth-1-yl)methyl)-4H-1,2,4-triazol-3-yl)thio)acetate (1c), and based on that discover a more potent URAT1 inhibitor. Methods: The SAR of 1c was systematically explored and the in vitro URAT1 inhibitory activity of synthesized compounds 1a-1t was determined by the inhibition of URAT1-mediated [8-14C]uric acid uptake by human embryonic kidney 293 (HEK293) cells stably expressing human URAT1. Results: Twenty compounds 1a-1t were synthesized. SAR analysis was performed. Two highly active URAT1 inhibitors, sodium 2-((5-bromo-4-((4-n-propylnaphth-1-yl)methyl)-4H-1,2,4-triazol-3-yl)thio)acetate (1j) and sodium 2-((5-bromo-4-((4-bromonaphth-1-yl)methyl)-4H-1,2,4-triazol-3-yl)thio)acetate (1m), were identified, which were 78- and 76-fold more active than parent lesinurad in in vitro URAT1 inhibitory assay, respectively (IC50 values for 1j and 1m were 0.092 μM and 0.094 μM, respectively, against human URAT1 vs 7.18 μM for lesinurad). Conclusion: Two highly active URAT1 inhibitors were discovered. The SAR exploration also identified more flexible naphthyltriazolylmethane as a novel molecular skeleton that will be valuable for the design of URAT1 inhibitors, as indicated by the observation that many of the synthesized naphthyltriazolylmethane-bearing derivatives (1b-1d, 1g, 1j and 1m) showed significantly improved UART1 inhibitory activity (sub-micromolar IC50 values) as compared with lesinurad which has the rigid naphthyltriazole skeleton.

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