(S)-3-[5-(3-bromophenyl)-5-fluoro-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-ylamino]-3-phenylpropan-1-ol

Base Information

Chemical Name:(S)-3-[5-(3-bromophenyl)-5-fluoro-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-ylamino]-3-phenylpropan-1-ol
CAS No.:1397712-73-0
Molecular Formula:C₂₀H₂₂BrFN₂O₄S
Molecular Weight:485.374
Hs Code.:

Synonyms:(S)-3-[5-(3-bromophenyl)-5-fluoro-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-ylamino]-3-phenylpropan-1-ol

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Chemical Property of (S)-3-[5-(3-bromophenyl)-5-fluoro-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-ylamino]-3-phenylpropan-1-ol

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Technology Process of (S)-3-[5-(3-bromophenyl)-5-fluoro-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-ylamino]-3-phenylpropan-1-ol

There total 5 articles about (S)-3-[5-(3-bromophenyl)-5-fluoro-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-ylamino]-3-phenylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-(3-bromophenyl)-2-ethoxy-5-fluoro-6,6-dimethyl-5,6-dihydro-[1,4,3]-oxathiazine 4,4-dioxide

: 82769-76-4
(S)-3-amino-3-phenylpropanol

: 1397712-73-0
(S)-3-[5-(3-bromophenyl)-5-fluoro-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-ylamino]-3-phenylpropan-1-ol

Guidance literature:: In dichloromethane; at 20 - 100 ℃; for 22.5h; Inert atmosphere;

Reference yield:

: 58236-74-1
(3-bromophenyl)methanesulfonyl chloride

: 1397712-73-0
(S)-3-[5-(3-bromophenyl)-5-fluoro-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-ylamino]-3-phenylpropan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.25 h / 20 °C / Cooling with ice

2.1: methyllithium / tetrahydrofuran; diethyl ether / -78 °C / Inert atmosphere

2.2: 0.17 h

2.3: 20 °C

3.1: methyllithium / tetrahydrofuran; diethyl ether / 0.17 h / -78 °C / Inert atmosphere

3.2: 0.17 h

3.3: 0.33 h / 20 °C

4.1: acetic acid / water / 5 h / 100 °C

5.1: dichloromethane / 22.5 h / 20 - 100 °C / Inert atmosphere

With methyllithium; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water;

Reference yield:

: 803727-93-7
N,N-bis(2,4-dimethoxybenzyl)-1-(3-bromophenyl)methanesulfonamide

: 1397712-73-0
(S)-3-[5-(3-bromophenyl)-5-fluoro-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-ylamino]-3-phenylpropan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: methyllithium / tetrahydrofuran; diethyl ether / -78 °C / Inert atmosphere

1.2: 0.17 h

1.3: 20 °C

2.1: methyllithium / tetrahydrofuran; diethyl ether / 0.17 h / -78 °C / Inert atmosphere

2.2: 0.17 h

2.3: 0.33 h / 20 °C

3.1: acetic acid / water / 5 h / 100 °C

4.1: dichloromethane / 22.5 h / 20 - 100 °C / Inert atmosphere

With methyllithium; acetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; water;