(E)-8-Benzenesulfonyl-2-(2-formyl-5-methoxy-phenyl)-oct-7-enoic acid methyl ester

Base Information

Chemical Name:(E)-8-Benzenesulfonyl-2-(2-formyl-5-methoxy-phenyl)-oct-7-enoic acid methyl ester
CAS No.:193215-63-3
Molecular Formula:C₂₃H₂₆O₆S
Molecular Weight:430.522
Hs Code.:

Synonyms:(E)-8-Benzenesulfonyl-2-(2-formyl-5-methoxy-phenyl)-oct-7-enoic acid methyl ester

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Chemical Property of (E)-8-Benzenesulfonyl-2-(2-formyl-5-methoxy-phenyl)-oct-7-enoic acid methyl ester

Chemical Property:

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Technology Process of (E)-8-Benzenesulfonyl-2-(2-formyl-5-methoxy-phenyl)-oct-7-enoic acid methyl ester

There total 9 articles about (E)-8-Benzenesulfonyl-2-(2-formyl-5-methoxy-phenyl)-oct-7-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 43088-72-8
6-Methoxyisochroman-3-one

: 193215-63-3
(E)-8-Benzenesulfonyl-2-(2-formyl-5-methoxy-phenyl)-oct-7-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 48 percent / NaH / benzene / 3 h / Heating

2: 64 percent / NaH / dimethylformamide / 1.) 60 deg C, 0.5 h, 2.) 16 h

3: 95 percent / aq. K₂CO₃ / methanol / 6 h / 50 °C

4: 1.) O₃, 2.) dimethyl sulfide / 1.) CH₂Cl₂, MeOH, -78 deg C, 0.5 h, 2.) r.t., 3 h

5: 66 percent / n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 10 min, 2.) -78 deg C, 2.5 h; -78 deg C to r.t., 1 h

6: 90 percent / Et₃N, methanesulfonyl chloride / CH₂Cl₂ / 1 h

7: aq. K₂CO₃ / methanol / 3.5 h / Ambient temperature

8: diethyl ether

9: 1.) DMSO, oxalyl chloride, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 0.5 h, 2.) -78 deg C to r.t.

With n-butyllithium; oxalyl dichloride; dimethylsulfide; sodium hydride; potassium carbonate; ozone; dimethyl sulfoxide; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1039/a701589e

Reference yield:

: 108164-24-5
4-(hex-5-enyl)-6-methoxyisochroman-3-one

: 193215-63-3
(E)-8-Benzenesulfonyl-2-(2-formyl-5-methoxy-phenyl)-oct-7-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) O₃, 2.) dimethyl sulfide / 1.) CH₂Cl₂, MeOH, -78 deg C, 0.5 h, 2.) r.t., 3 h

2: 66 percent / n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 10 min, 2.) -78 deg C, 2.5 h; -78 deg C to r.t., 1 h

3: 90 percent / Et₃N, methanesulfonyl chloride / CH₂Cl₂ / 1 h

4: aq. K₂CO₃ / methanol / 3.5 h / Ambient temperature

5: diethyl ether

6: 1.) DMSO, oxalyl chloride, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 0.5 h, 2.) -78 deg C to r.t.

With n-butyllithium; oxalyl dichloride; dimethylsulfide; potassium carbonate; ozone; dimethyl sulfoxide; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane;
DOI:10.1039/a701589e

Reference yield:

: 18922-04-8
6-iodohex-1-ene

: 193215-63-3
(E)-8-Benzenesulfonyl-2-(2-formyl-5-methoxy-phenyl)-oct-7-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 64 percent / NaH / dimethylformamide / 1.) 60 deg C, 0.5 h, 2.) 16 h

2: 95 percent / aq. K₂CO₃ / methanol / 6 h / 50 °C

3: 1.) O₃, 2.) dimethyl sulfide / 1.) CH₂Cl₂, MeOH, -78 deg C, 0.5 h, 2.) r.t., 3 h

4: 66 percent / n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 10 min, 2.) -78 deg C, 2.5 h; -78 deg C to r.t., 1 h

5: 90 percent / Et₃N, methanesulfonyl chloride / CH₂Cl₂ / 1 h

6: aq. K₂CO₃ / methanol / 3.5 h / Ambient temperature

7: diethyl ether

8: 1.) DMSO, oxalyl chloride, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 0.5 h, 2.) -78 deg C to r.t.

With n-butyllithium; oxalyl dichloride; dimethylsulfide; sodium hydride; potassium carbonate; ozone; dimethyl sulfoxide; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/a701589e