43088-72-8

Upstream product

• 124619-00-7 (5-Methoxy-2-methoxymethyl-phenyl)-acetonitrile 
• 111210-24-3 2-bromo-1-methoxy-4-(methoxymethyl)benzene 
• 74317-85-4 2-bromo-4-methoxybenzoic acid 
• 50-00-0 formaldehyd 
• 1798-09-0 m-methoxyphenylacetic acid 
• 68294-03-1 2-(carboxymethyl)-4-methoxybenzoic acid 
• 24672-87-5 4-methoxy-2-(2-methoxy-2-oxoethyl)benzoic acid 
• 76413-89-3 5-methoxy-2-indanone 

Downstream Products

• 1097777-91-7 methyl [2-(bromomethyl)-5-(methyloxy)phenyl]acetate 
• 98748-62-0 2-(2-hydroxymethyl-5-methoxyphenyl)-3-(3-methoxyphenyl)-N-methylpropionamide 
• 98748-60-8 methyl 2-formyl-5-methoxyphenyl-3'-methoxybenzyl acetate 
• 98748-59-5 6-methoxy-4-(3-methoxybenzyl)isochroman-3-one 
• 98748-63-1 2-(2-hydroxymethyl-5-methoxyphenyl)-3-(3-methoxyphenyl)-N-methylpropylamine 
• 98748-64-2 1,2,3,4-tetrahydro-6-methoxy-4-(3-methoxybenzyl)-2-methylisoquinoline 
• 161141-55-5 4-(4,4-Dimethyl-6-phenylsulfonylhex-5-enyl)-6-methoxychroman-3-one 
• 161141-57-7 2-(2-Formyl-5-methoxyphenyl)-6,6-dimethyl-8-phenylsulfonyloct-7-enoic acid 
• 176911-29-8 Methyl 2-(2-hydroxymethyl-5-methoxyphenyl)-6,6-dimethyloct-7-enoate 
• 176911-30-1 Methyl 2-(2-formyl-5-methoxyphenyl)-6,6-dimethyloct-7-enoate 
• 161141-49-7 2-(2-Formyl-5-methoxyphenyl)-6,6-dimethyloct-7-enoic acid 
• 193215-61-1 4-(6-Benzenesulfonyl-5-hydroxy-hexyl)-6-methoxy-isochroman-3-one 
• 193215-70-2 (E)-8-Benzenesulfonyl-2-(2-hydroxymethyl-5-methoxy-phenyl)-oct-7-enoic acid methyl ester 
• 193215-63-3 (E)-8-Benzenesulfonyl-2-(2-formyl-5-methoxy-phenyl)-oct-7-enoic acid methyl ester 

Relevant academic research and scientific papers

Nickel-Catalyzed Desymmetrizing Cyclization of 1,6-Dienes to Construct Quaternary Stereocenters

A highly enantioselective and diastereoselective nickel-catalyzed desymmetrizing cyclization of 1,6-dienes was developed by using chiral spiro phosphoramidite ligands. The reaction provides a new atom- and step-economical approach to chiral spiro lactones and analogues bearing a quaternary stereocenter.

Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: Potential scaffolds for estrogen receptor modulation and/or microtubule degradation

6-Methoxytetrahydroisoquinoline hydrochloride was converted into four small libraries of substituted ureas, thioureas, sulfonamides and N-aryls, using the tetrahydroisoquinoline nitrogen as the scaffold-linking atom. Some of the compounds were evaluated for their ability to inhibit cell proliferation using the MCF7 (invasive ductal carcinoma) cell line.

Synthesis of Isoindoles from Intramolecular Condensation of Benzyl Azides with α-Aryldiazoesters

Rh-catalyzed intramolecular condensation of the benzyl azides with α-aryldiazoesters was explored. The reaction proceeded through the nucleophilic attack of the organic azide onto a rhodium carbenoid, while releasing nitrogen gas, affording the α-imino es

Preparation of Novel 4-Substituted 6-Methoxy, 6,7-Dimethoxy-, and 6,7-(Methylenedioxy)isochroman-3-ones. 2

The title compounds 20, 21, and 22 have been prepared in modest yields by a two-step reaction involving first the reaction of bromoarenes 3, 7, and 8 with lithioalkyl- and lithioarylacetonitriles under aryne-forming conditions.The cyano products 10, 14, and 16 so formed were then converted to the corresponding isochroman-3-ones by acidic hydrolysis.