N-(3,4-dimethoxyphenyl)-2-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid ethyl ester

Base Information

Chemical Name:N-(3,4-dimethoxyphenyl)-2-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid ethyl ester
CAS No.:1059183-05-9
Molecular Formula:C₂₉H₃₀F₃NO₅
Molecular Weight:529.556
Hs Code.:

Synonyms:N-(3,4-dimethoxyphenyl)-2-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid ethyl ester

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Chemical Property of N-(3,4-dimethoxyphenyl)-2-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid ethyl ester

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Technology Process of N-(3,4-dimethoxyphenyl)-2-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid ethyl ester

There total 3 articles about N-(3,4-dimethoxyphenyl)-2-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1059182-78-3
(3,4-dimethoxy-phenyl)-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine

: 91393-67-8
methyl-phenyl-malonic acid ethyl ester chloride

: 1059183-05-9
N-(3,4-dimethoxyphenyl)-2-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 6315-89-5
3,4-dimethoxyaniline

: 1059183-05-9
N-(3,4-dimethoxyphenyl)-2-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

3: triethylamine / dichloromethane / 16 h / 20 °C

With lithium aluminium tetrahydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 32857-62-8
4-Trifluoromethylphenylacetic acid

: 1059183-05-9
N-(3,4-dimethoxyphenyl)-2-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

3: triethylamine / dichloromethane / 16 h / 20 °C

With lithium aluminium tetrahydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;