N-(3,4-dimethoxyphenyl)-2,N',N'-trimethyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamide

Base Information

Chemical Name:N-(3,4-dimethoxyphenyl)-2,N',N'-trimethyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamide
CAS No.:1059182-75-0
Molecular Formula:C₂₉H₃₁F₃N₂O₄
Molecular Weight:528.571
Hs Code.:

Synonyms:N-(3,4-dimethoxyphenyl)-2,N',N'-trimethyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamide

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Chemical Property of N-(3,4-dimethoxyphenyl)-2,N',N'-trimethyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamide

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Technology Process of N-(3,4-dimethoxyphenyl)-2,N',N'-trimethyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamide

There total 5 articles about N-(3,4-dimethoxyphenyl)-2,N',N'-trimethyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1059183-05-9
N-(3,4-dimethoxyphenyl)-2-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid ethyl ester

: 124-40-3
dimethyl amine

: 1059182-75-0
N-(3,4-dimethoxyphenyl)-2,N',N'-trimethyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamide

Guidance literature:: N-(3,4-dimethoxyphenyl)-2-methyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamic acid ethyl ester; With potassium hydroxide; sodium hydroxide; water; In ethanol; at 80 ℃;

dimethyl amine; In ethanol; N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 6315-89-5
3,4-dimethoxyaniline

: 1059182-75-0
N-(3,4-dimethoxyphenyl)-2,N',N'-trimethyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

3.1: triethylamine / dichloromethane / 16 h / 20 °C

4.1: potassium hydroxide; sodium hydroxide; water / ethanol / 80 °C

4.2: 16 h / 20 °C

With potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1059182-78-3
(3,4-dimethoxy-phenyl)-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine

: 1059182-75-0
N-(3,4-dimethoxyphenyl)-2,N',N'-trimethyl-2-phenyl-N-[2-(4-trifluoromethylphenyl)ethyl]malonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 16 h / 20 °C

2.1: potassium hydroxide; sodium hydroxide; water / ethanol / 80 °C

2.2: 16 h / 20 °C

With potassium hydroxide; sodium hydroxide; water; triethylamine; In ethanol; dichloromethane;