(5R)-5-(azidomethyl)-3-(4-(4-((5-(2,4-difluorophenyl)-1-(4-fluorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)oxazolidin-2-one

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Chemical Name:(5R)-5-(azidomethyl)-3-(4-(4-((5-(2,4-difluorophenyl)-1-(4-fluorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)oxazolidin-2-one
CAS No.:1445874-29-2
Molecular Formula:C₃₂H₂₉F₄N₇O₂
Molecular Weight:619.622
Hs Code.:

Synonyms:(5R)-5-(azidomethyl)-3-(4-(4-((5-(2,4-difluorophenyl)-1-(4-fluorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)oxazolidin-2-one

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Chemical Property of (5R)-5-(azidomethyl)-3-(4-(4-((5-(2,4-difluorophenyl)-1-(4-fluorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)oxazolidin-2-one

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Technology Process of (5R)-5-(azidomethyl)-3-(4-(4-((5-(2,4-difluorophenyl)-1-(4-fluorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)oxazolidin-2-one

There total 3 articles about (5R)-5-(azidomethyl)-3-(4-(4-((5-(2,4-difluorophenyl)-1-(4-fluorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 221201-21-4
(R)-5-(azidomethyl)-3-(3-fluoro-4-(piperazin-1-yl)phenyl)oxazolidin-2-one

: 908292-46-6
1-(4-fluorophenyl)-2-methyl-5-(2,4-difluorophenyl)-1H-pyrrole

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1445874-29-2
(5R)-5-(azidomethyl)-3-(4-(4-((5-(2,4-difluorophenyl)-1-(4-fluorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)oxazolidin-2-one

Guidance literature:: With acetic acid; In water; acetonitrile; at 0 - 30 ℃; for 6h;
DOI:10.1016/j.ejmech.2013.03.027

Reference yield:

: 1550-35-2
2,4-difluorobenzaldehyde

: 1445874-29-2
(5R)-5-(azidomethyl)-3-(4-(4-((5-(2,4-difluorophenyl)-1-(4-fluorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / 5 h / 75 - 78 °C

2: gadolinium(III) trifluoromethanesulfonate / acetonitrile / 0.5 h / 30 °C

3: acetic acid / acetonitrile; water / 6 h / 0 - 30 °C

With acetic acid; triethylamine; gadolinium(III) trifluoromethanesulfonate; In water; acetonitrile; 1: |Stetter 1,4-Dicarbonyl Synthesis / 2: |Paal-Knorr Pyrrole Synthesis / 3: |Mannich Aminomethylation;
DOI:10.1016/j.ejmech.2013.03.027

Reference yield:

: 908292-39-7
1-(2,4-difluorophenyl)pentane-1,4-dione

: 1445874-29-2
(5R)-5-(azidomethyl)-3-(4-(4-((5-(2,4-difluorophenyl)-1-(4-fluorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: gadolinium(III) trifluoromethanesulfonate / acetonitrile / 0.5 h / 30 °C

2: acetic acid / acetonitrile; water / 6 h / 0 - 30 °C

With acetic acid; gadolinium(III) trifluoromethanesulfonate; In water; acetonitrile; 1: |Paal-Knorr Pyrrole Synthesis / 2: |Mannich Aminomethylation;
DOI:10.1016/j.ejmech.2013.03.027