4-[Bis-(2-chloro-ethyl)-amino]-cyclohexanecarboxylic acid ethyl ester; hydrochloride

Base Information

• Chemical Name: 4-[Bis-(2-chloro-ethyl)-amino]-cyclohexanecarboxylic acid ethyl ester; hydrochloride
• CAS No.: 78431-94-4
• Molecular Formula: C₁₃H₂₃Cl₂NO₂*ClH
• Molecular Weight: 332.698

Synonyms:4-[Bis-(2-chloro-ethyl)-amino]-cyclohexanecarboxylic acid ethyl ester; hydrochloride

Chemical Property of 4-[Bis-(2-chloro-ethyl)-amino]-cyclohexanecarboxylic acid ethyl ester; hydrochloride

Chemical Property:

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Technology Process of 4-[Bis-(2-chloro-ethyl)-amino]-cyclohexanecarboxylic acid ethyl ester; hydrochloride

There total 2 articles about 4-[Bis-(2-chloro-ethyl)-amino]-cyclohexanecarboxylic acid ethyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

4-[Bis-(2-hydroxy-ethyl)-amino]-cyclohexanecarboxylic acid ethyl ester (78431-91-1) → 4-[Bis-(2-chloro-ethyl)-amino]-cyclohexanecarboxylic acid ethyl ester; hydrochloride (78431-94-4)

Guidance literature:

With thionyl chloride; In chloroform; at 20 ℃; for 1h;

DOI:10.1007/BF00962271

Reference yield:

cis-4-amino-cyclohexanecarboxylic acid ethyl ester (1678-68-8,3685-28-7,51498-33-0) → 4-[Bis-(2-chloro-ethyl)-amino]-cyclohexanecarboxylic acid ethyl ester; hydrochloride (78431-94-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / H₂O

2: 44 percent / SOCl₂ / CHCl₃ / 1 h / 20 °C

With thionyl chloride; In chloroform; water;

DOI:10.1007/BF00962271

Reference yield: 89.0%

4-[Bis-(2-chloro-ethyl)-amino]-cyclohexanecarboxylic acid ethyl ester; hydrochloride (78431-94-4) → 4-[Bis-(2-chloro-ethyl)-amino]-cyclohexanecarboxylic acid; hydrochloride (78431-97-7)

Guidance literature:

With hydrogenchloride; for 1.5h; Heating;

DOI:10.1007/BF00962271

upstream raw materials:

4-[Bis-(2-hydroxy-ethyl)-amino]-cyclohexanecarboxylic acid ethyl ester

cis-4-amino-cyclohexanecarboxylic acid ethyl ester

Downstream raw materials:

4-[Bis-(2-chloro-ethyl)-amino]-cyclohexanecarboxylic acid; hydrochloride

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