TRANS-4-AMINOCYCLOHEXANE CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: TRANS-4-AMINOCYCLOHEXANE CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 1678-68-8
• Molecular Formula: C9H17NO2
• Molecular Weight: 171.239
• Hs Code.: 2922499990
• Mol file: 1678-68-8.mol

Synonyms:(trans-4-Carboethoxycyclohexyl)amine;Ethyl trans-4-aminocyclohexanecarboxylate;Ethyl trans-4-aminocyclohexanecarboxylate;trans-4-Aminocyclohexanecarboxylic acid ethyl ester;

Chemical Property of TRANS-4-AMINOCYCLOHEXANE CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Appearance/Colour: Yellow Solid
• Refractive Index: 1.469
• Boiling Point: 139-140℃ (13 Torr)
• PKA: 10.36±0.70(Predicted)
• PSA: 52.32000
• Density: 1.018±0.06 g/cm3(Predicted)
• LogP: 1.76730
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

Ethyltrans-4-aminocyclohexanecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TRANS-4-AMINOCYCLOHEXANE CARBOXYLIC ACID ETHYL ESTER

There total 9 articles about TRANS-4-AMINOCYCLOHEXANE CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethanol (64-17-5) + trans-4-aminocyclohexanecarboxylic acid hydrochloric acid (27960-59-4) → ethyl trans-4-aminocyclohexanecarboxylate (1678-68-8)

Guidance literature:

With hydrogenchloride; at 60 ℃;

Reference yield:

ethanol (64-17-5) + trans-4-aminocyclohexanecarboxylic acid (1776-53-0,3685-23-2,3685-25-4,57043-03-5,66762-20-7) → ethyl trans-4-aminocyclohexanecarboxylate (1678-68-8)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/jm00289a011

Reference yield:

p-aminoethylbenzoate (94-09-7) → ethyl trans-4-aminocyclohexanecarboxylate (1678-68-8) + cis-4-amino-cyclohexanecarboxylic acid ethyl ester (1678-68-8,3685-28-7,51498-33-0)

Guidance literature:

With hydrogen; ruthenium on aluminium oxide; In diethylene glycol dimethyl ether; at 120 - 170 ℃; for 2 - 8h; under 15001.5 - 37503.8 Torr; Product distribution / selectivity;

upstream raw materials:

ethanol

trans-4-aminocyclohexanecarboxylic acid

ethyl 4-amino-1-cyclohexanecarboxylate

p-aminoethylbenzoate

Downstream raw materials:

N--N'-<2-chlor-aethyl>-harnstoff

4-[Bis-(2-hydroxy-ethyl)-amino]-cyclohexanecarboxylic acid ethyl ester

C₁₃H₂₄Cl₃N₂O₃P

C₁₃H₂₄Cl₃N₂O₃P