6-(benzyloxy)-1-(methylsulfonyl)-3-<<(methylsulfonyl)oxy>methyl>indoline

Base Information

• Chemical Name: 6-(benzyloxy)-1-(methylsulfonyl)-3-<<(methylsulfonyl)oxy>methyl>indoline
• CAS No.: 106014-85-1
• Molecular Formula: C₁₈H₂₁NO₆S₂
• Molecular Weight: 411.5
• Mol file: 106014-85-1.mol

Synonyms:6-(benzyloxy)-1-(methylsulfonyl)-3-<<(methylsulfonyl)oxy>methyl>indoline

Chemical Property of 6-(benzyloxy)-1-(methylsulfonyl)-3-<<(methylsulfonyl)oxy>methyl>indoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(benzyloxy)-1-(methylsulfonyl)-3-<<(methylsulfonyl)oxy>methyl>indoline

There total 8 articles about 6-(benzyloxy)-1-(methylsulfonyl)-3-<<(methylsulfonyl)oxy>methyl>indoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-<2-amino-4-(benzyloxy)phenyl>propane-1,3-diol (106014-84-0) + methanesulfonyl chloride (124-63-0) → 6-(benzyloxy)-1-(methylsulfonyl)-3-<<(methylsulfonyl)oxy>methyl>indoline (106014-85-1)

Guidance literature:

In pyridine; at 0 ℃;

DOI:10.1016/S0040-4039(00)84921-7

Reference yield:

2-[4-(benzyloxy)-2-nitrophenyl]propane-1,3-diol (106014-83-9) → 6-(benzyloxy)-1-(methylsulfonyl)-3-<<(methylsulfonyl)oxy>methyl>indoline (106014-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / hydrogen / 84.5percent PtO₂ / ethanol / 2.75 h / 2327.2 Torr

2: 111 g / pyridine / 1.42 h / 5 °C

With pyridine; hydrogen; platinum(IV) oxide; In ethanol;

DOI:10.1021/jm00398a017

Reference yield:

4-benzyloxy-2-nitro-chlorobenzene (79035-13-5) → 6-(benzyloxy)-1-(methylsulfonyl)-3-<<(methylsulfonyl)oxy>methyl>indoline (106014-85-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 77 percent / NaH / dimethylsulfoxide / 24 h / 105 - 115 °C

2: 40 percent / diisobutylaluminum hydride / tetrahydrofuran / 2.3 h / Ambient temperature

3: 69 percent / hydrogen / 84.5percent PtO₂ / ethanol / 2.75 h / 2327.2 Torr

4: 111 g / pyridine / 1.42 h / 5 °C

With pyridine; hydrogen; sodium hydride; diisobutylaluminium hydride; platinum(IV) oxide; In tetrahydrofuran; ethanol; dimethyl sulfoxide;

DOI:10.1021/jm00398a017

upstream raw materials:

2-<2-amino-4-(benzyloxy)phenyl>propane-1,3-diol

methanesulfonyl chloride

3-nitro-4-chlorophenol

2-[4-(benzyloxy)-2-nitrophenyl]propane-1,3-diol

Downstream raw materials:

6-(benzyloxy)-2,3-dihydro-1-(methylsulfonyl)-1H-indole-3-methanol acetate

6-benzyloxy-3-hydroxymethyl-2,3-dihydro-1H-indole

6-(benzyloxy)-3-(chloromethyl)-1-(methylsulfonyl)indoline

6-(benzyloxy)-3-(chloromethyl)-5-formyl-1-(methylsulfonyl)indoline