2S,3S-1-BOC-2-METHYL-PIPERIDINE-3-CARBOXYLIC ACID

Base Information

• Chemical Name: 2S,3S-1-BOC-2-METHYL-PIPERIDINE-3-CARBOXYLIC ACID
• CAS No.: 828300-45-4
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 243.303
• Mol file: 828300-45-4.mol

Synonyms:2S,3S-1-BOC-2-METHYL-PIPERIDINE-3-CARBOXYLIC ACID

Chemical Property of 2S,3S-1-BOC-2-METHYL-PIPERIDINE-3-CARBOXYLIC ACID

Chemical Property:

• PSA: 66.84000
• LogP: 2.04450

Purity/Quality:

97% ^*data from raw suppliers

cis-1-Boc-2-methyl-piperidine-3-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2S,3S-1-BOC-2-METHYL-PIPERIDINE-3-CARBOXYLIC ACID

There total 22 articles about 2S,3S-1-BOC-2-METHYL-PIPERIDINE-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl trans-N-tert-butoxycarbonyl-2-methylnipecotate → trans-(±)-1-(tert-butoxycarbonyl)-2-methylpiperidine-3-carboxylic acid (828300-51-2,828300-45-4)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1016/j.tet.2004.10.039

Reference yield: 100.0%

ethyl cis-N-tert-butoxycarbonyl-2-methylnipecotate → (2R*,3R*)-1-[(tert-butoxy)carbonyl]-2-methylpiperidine-3-carboxylic acid (828300-51-2,828300-45-4)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1016/j.tet.2004.10.039

Reference yield: 99.0%

1-tert-butyl 3-methyl (2R,3R)-2-methylpiperidine-1,3-dicarboxylate (929282-63-3) → (2R,3R)-1-[(tert-butoxy)carbonyl]-2-methylpiperidine-3-carboxylic acid (828300-51-2,828300-45-4)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

upstream raw materials:

methyl-2 nipecotate d'ethyle

di-tert-butyl dicarbonate

methyl 2-methylnicotinate

methanol