tert-butyl 2-(1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 2-(1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate
• CAS No.: 359804-43-6
• Molecular Formula: C₁₆H₂₁N₃O₂
• Molecular Weight: 287.362
• Mol file: 359804-43-6.mol

Synonyms:tert-butyl 2-(1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate

Chemical Property of tert-butyl 2-(1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of tert-butyl 2-(1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate

There total 1 articles about tert-butyl 2-(1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

benzoimidazole (51-17-2,79351-71-6) + tert-butyl pyrrolidine-1-carboxylate (86953-79-9) → tert-butyl 2-(1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate (359804-43-6)

Guidance literature:

With tert-butyl peroxyacetate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; trifluoroacetic acid; In acetone; at 20 ℃; for 24h; Irradiation; Sealed tube; Green chemistry;

DOI:10.1021/acs.orglett.8b02389

Reference yield: 99.1%

tert-butyl 2-(1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate (359804-43-6) + diethyl ether (60-29-7,927820-24-4) → 2-(pyrrolidin-2-yl)-1H-benzo[d]imidazole (59592-35-7,175530-90-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

upstream raw materials:

benzoimidazole

tert-butyl pyrrolidine-1-carboxylate

Downstream raw materials:

2-(pyrrolidin-2-yl)-1H-benzo[d]imidazole