7-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-fluoro-4-(furan-3-yl)-7H-pyrrolo[2,3-d]pyrimidine

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Chemical Name:7-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-fluoro-4-(furan-3-yl)-7H-pyrrolo[2,3-d]pyrimidine
CAS No.:1338073-04-3
Molecular Formula:C₂₉H₂₁F₂N₃O₆
Molecular Weight:545.499
Hs Code.:

Synonyms:7-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-fluoro-4-(furan-3-yl)-7H-pyrrolo[2,3-d]pyrimidine

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Chemical Property of 7-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-fluoro-4-(furan-3-yl)-7H-pyrrolo[2,3-d]pyrimidine

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Technology Process of 7-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-fluoro-4-(furan-3-yl)-7H-pyrrolo[2,3-d]pyrimidine

There total 2 articles about 7-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-fluoro-4-(furan-3-yl)-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 909101-46-8
4-chloro-7-(2-deoxy-3,5-di-O-benzoyl-β-D-arabinofuranosyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine

: 55552-70-0
furan-3-boronic acid

: 1338073-04-3
7-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-fluoro-4-(furan-3-yl)-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In toluene; at 100 ℃; for 3h; Inert atmosphere;
DOI:10.1135/cccc2011082

Reference yield:

: 98855-71-1
((2R,3R,4S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydrofuran-2-yl)methyl benzoate

: 1338073-04-3
7-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-fluoro-4-(furan-3-yl)-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: Tris(3,6-dioxaheptyl)amine; potassium hydroxide / acetonitrile / 0.25 h / 20 °C

1.2: 0.17 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene / 3 h / 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; Tris(3,6-dioxaheptyl)amine; potassium carbonate; potassium hydroxide; In toluene; acetonitrile;
DOI:10.1135/cccc2011082