(2R,3R)-2-(4-benzyloxy-3-methoxybenzyl)-3-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide

Base Information

Chemical Name:(2R,3R)-2-(4-benzyloxy-3-methoxybenzyl)-3-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide
CAS No.:939963-14-1
Molecular Formula:C₄₃H₅₄O₇Si
Molecular Weight:710.983
Hs Code.:

Synonyms:(2R,3R)-2-(4-benzyloxy-3-methoxybenzyl)-3-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide

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Chemical Property of (2R,3R)-2-(4-benzyloxy-3-methoxybenzyl)-3-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide

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Technology Process of (2R,3R)-2-(4-benzyloxy-3-methoxybenzyl)-3-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide

There total 1 articles about (2R,3R)-2-(4-benzyloxy-3-methoxybenzyl)-3-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 868127-82-6
(3R)-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide

: 72724-00-6
1-(benzyloxy)-4-(bromomethyl)-2-methoxybenzene

: 939963-14-1
(2R,3R)-2-(4-benzyloxy-3-methoxybenzyl)-3-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide

Guidance literature:: (3R)-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide; With potassium hexamethyldisilazane; In tetrahydrofuran; toluene; at -70 ℃; for 0.25h;

1-(benzyloxy)-4-(bromomethyl)-2-methoxybenzene; In tetrahydrofuran; toluene; at -70 ℃; for 0.5h; Further stages.;
DOI:10.1271/bbb.60096

Reference yield:

: 939963-14-1
(2R,3R)-2-(4-benzyloxy-3-methoxybenzyl)-3-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide

: C₃₄H₃₄O₇

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1271/bbb.60096

Reference yield:

: 939963-14-1
(2R,3R)-2-(4-benzyloxy-3-methoxybenzyl)-3-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide

: 53250-61-6
7-Oxomatairesinol

Guidance literature:: Multi-step reaction with 3 steps

1: n-Bu₄NF / tetrahydrofuran / 1 h / 0 °C

2: pyridinium chlorochromate; 4 Angstroem molecular sieves / CH₂Cl₂ / 16 h / 20 °C

3: 67 percent / H₂ / Pd-C / ethyl acetate / 2 h / 20 °C

With 4 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1271/bbb.60096