1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acid [2-(2,2,2-trfluoro-acetylamino)-ethyl]-amide

Base Information

Chemical Name:1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acid [2-(2,2,2-trfluoro-acetylamino)-ethyl]-amide
CAS No.:1392842-57-7
Molecular Formula:C₂₆H₂₁F₃N₄O₄
Molecular Weight:510.472
Hs Code.:

Synonyms:1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acid [2-(2,2,2-trfluoro-acetylamino)-ethyl]-amide

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Chemical Property of 1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acid [2-(2,2,2-trfluoro-acetylamino)-ethyl]-amide

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Technology Process of 1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acid [2-(2,2,2-trfluoro-acetylamino)-ethyl]-amide

There total 8 articles about 1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acid [2-(2,2,2-trfluoro-acetylamino)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 383-63-1
ethyl trifluoroacetate,

: 1392839-56-3
{2-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester

: 1392842-57-7
1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acid [2-(2,2,2-trfluoro-acetylamino)-ethyl]-amide

Guidance literature:: {2-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

ethyl trifluoroacetate,; With triethylamine; In dichloromethane; Reflux;

Reference yield:

: 100-46-9
benzylamine

: 1392842-57-7
1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acid [2-(2,2,2-trfluoro-acetylamino)-ethyl]-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: methanol / 2 h / Reflux

1.2: 48 h / Reflux

2.1: sodium methylate; N-Bromosuccinimide / methanol / 1 h / Reflux

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

4.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 72 h / 20 °C

5.1: sodium methylate / methanol / 5 h

6.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

7.1: ethanol / 48 h / Reflux

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

8.2: Reflux

With N-Bromosuccinimide; sodium methylate; potassium carbonate; trifluoroacetic acid; sodium iodide; dibenzoyl peroxide; bis-triphenylphosphine-palladium(II) chloride; In methanol; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1392838-68-4
1-benzyl-3-bromo-5-hydroxy-2-oxo-1,2-dihydro-[1,7]-naphthyridine-6-carboxylic acid methyl ester

: 1392842-57-7
1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acid [2-(2,2,2-trfluoro-acetylamino)-ethyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

2.1: ethanol / 48 h / Reflux

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.2: Reflux

With trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In ethanol; dichloromethane; N,N-dimethyl-formamide;