2-[2-(2-tritylaminoethylcarbonylamino)-1,3-thiazol-4-yl]acetic acid

Base Information

• Chemical Name: 2-[2-(2-tritylaminoethylcarbonylamino)-1,3-thiazol-4-yl]acetic acid
• CAS No.: 945469-76-1
• Molecular Formula: C₂₇H₂₅N₃O₃S
• Molecular Weight: 471.58
• Mol file: 945469-76-1.mol

Synonyms:2-[2-(2-tritylaminoethylcarbonylamino)-1,3-thiazol-4-yl]acetic acid

Chemical Property of 2-[2-(2-tritylaminoethylcarbonylamino)-1,3-thiazol-4-yl]acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(2-tritylaminoethylcarbonylamino)-1,3-thiazol-4-yl]acetic acid

There total 1 articles about 2-[2-(2-tritylaminoethylcarbonylamino)-1,3-thiazol-4-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-amino-1,3-thiazol-4-acetate (53266-94-7) → 2-[2-(2-tritylaminoethylcarbonylamino)-1,3-thiazol-4-yl]acetic acid (945469-76-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 74.7 percent / 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / ethyl acetate; dimethylformamide / cooling

2: 92.7 percent / NaOH / methanol; H₂O / 1 h / 20 °C

With sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In methanol; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1080/00908320701230117

Reference yield: 87.2%

2-[2-(2-tritylaminoethylcarbonylamino)-1,3-thiazol-4-yl]acetic acid (945469-76-1) + H-Asp(Bzl)-Phe-OBzl hydrochloride → C54H51N5O7S (945469-78-3)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; cooling;

DOI:10.1080/00908320701230117

Reference yield:

2-[2-(2-tritylaminoethylcarbonylamino)-1,3-thiazol-4-yl]acetic acid (945469-76-1) → C35H37N5O7S*C2H4O2

Guidance literature:

Multi-step reaction with 2 steps

1: 87.2 percent / 1-hydroxybenzotriazole; dicyclohexylcarbodiimide; triethylamine / dimethylformamide; CH₂Cl₂ / cooling

2: 91.87 percent / water / 0.17 h / 100 °C

With water; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1080/00908320701230117

upstream raw materials:

ethyl 2-amino-1,3-thiazol-4-acetate

Downstream raw materials:

C₅₄H₅₁N₅O₇S

C₅₂H₅₁N₇O₁₁S