N-[2-(2-fluoroethoxy)pyridin-3-ylmethyl]-N-(2-phenoxy-phenyl)acetamide

Base Information

Chemical Name:N-[2-(2-fluoroethoxy)pyridin-3-ylmethyl]-N-(2-phenoxy-phenyl)acetamide
CAS No.:1245623-88-4
Molecular Formula:C₂₂H₂₁FN₂O₃
Molecular Weight:380.419
Hs Code.:

Synonyms:N-[2-(2-fluoroethoxy)pyridin-3-ylmethyl]-N-(2-phenoxy-phenyl)acetamide

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Chemical Property of N-[2-(2-fluoroethoxy)pyridin-3-ylmethyl]-N-(2-phenoxy-phenyl)acetamide

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Technology Process of N-[2-(2-fluoroethoxy)pyridin-3-ylmethyl]-N-(2-phenoxy-phenyl)acetamide

There total 9 articles about N-[2-(2-fluoroethoxy)pyridin-3-ylmethyl]-N-(2-phenoxy-phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1245623-87-3
N-(2-hydroxypyridin-3-ylmethyl)-N-(2-phenoxy-phenyl)acetamide

: 383-50-6
2-fluoroethyl tosylate

: 1245623-88-4
N-[2-(2-fluoroethoxy)pyridin-3-ylmethyl]-N-(2-phenoxy-phenyl)acetamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 24h; Inert atmosphere;

Reference yield:

: 2216-12-8
1-nitro-2-phenoxy-benzene

: 1245623-88-4
N-[2-(2-fluoroethoxy)pyridin-3-ylmethyl]-N-(2-phenoxy-phenyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen; palladium on activated charcoal / methanol / 0.5 h / 20 - 50 °C

2.1: hydrogen / 1 h / 90 °C

2.2: 24 h / 20 °C

2.3: 0.25 h

3.1: dmap / dichloromethane / 3 h / 0 - 20 °C

4.1: hydrogen bromide / water / 24 h / 100 °C / Inert atmosphere

5.1: dmap / dichloromethane / 24 h / 0 - 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 70 °C / Inert atmosphere

With dmap; palladium on activated charcoal; hydrogen bromide; hydrogen; potassium carbonate; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 2688-84-8
2-phenoxyaniline

: 1245623-88-4
N-[2-(2-fluoroethoxy)pyridin-3-ylmethyl]-N-(2-phenoxy-phenyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / 1 h / 90 °C

1.2: 24 h / 20 °C

1.3: 0.25 h

2.1: dmap / dichloromethane / 3 h / 0 - 20 °C

3.1: hydrogen bromide / water / 24 h / 100 °C / Inert atmosphere

4.1: dmap / dichloromethane / 24 h / 0 - 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 70 °C / Inert atmosphere

With dmap; hydrogen bromide; hydrogen; potassium carbonate; In dichloromethane; water; N,N-dimethyl-formamide;