(S)-2-(3-{4-[3-(2-Amino-ethyl)-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid pentafluorophenyl ester; hydrochloride

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Chemical Name:(S)-2-(3-{4-[3-(2-Amino-ethyl)-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid pentafluorophenyl ester; hydrochloride
CAS No.:120363-35-1
Molecular Formula:C₃₂H₂₇F₅N₂O₅*ClH
Molecular Weight:651.03
Hs Code.:

Synonyms:(S)-2-(3-{4-[3-(2-Amino-ethyl)-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid pentafluorophenyl ester; hydrochloride

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Chemical Property of (S)-2-(3-{4-[3-(2-Amino-ethyl)-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid pentafluorophenyl ester; hydrochloride

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Technology Process of (S)-2-(3-{4-[3-(2-Amino-ethyl)-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid pentafluorophenyl ester; hydrochloride

There total 13 articles about (S)-2-(3-{4-[3-(2-Amino-ethyl)-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid pentafluorophenyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 621-54-5
3-(3-hydroxyphenyl)-propanoic acid

: 120363-35-1
(S)-2-(3-{4-[3-(2-Amino-ethyl)-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid pentafluorophenyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1: 100 percent / NaH, n-Bu₄NI / dimethylformamide / 10 h / 25 °C

2: Et₃N, DPPA / 8 h / 85 °C

3: H₂ / 10percent Pd/C / tetrahydrofuran / 6 h / 25 °C / 2280 Torr

5: 97 percent / H₂ / 10percent Pd/C / methanol / 3 h / 25 °C / 2280 Torr

6: LiOH, H₂O / methanol; tetrahydrofuran

7: EDCI / dimethylformamide / 25 °C

8: LiOH, H₂O / methanol; tetrahydrofuran / 25 °C

9: EDCI / CH₂Cl₂ / 25 °C

10: 3.0M HCl / ethyl acetate

With hydrogenchloride; lithium hydroxide; diphenyl-phosphinic acid; water; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00311a019

Reference yield:

: 57668-34-5
3-(3-(benzyloxy)phenyl)propanoic acid

: 120363-35-1
(S)-2-(3-{4-[3-(2-Amino-ethyl)-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid pentafluorophenyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: Et₃N, DPPA / 8 h / 85 °C

2: H₂ / 10percent Pd/C / tetrahydrofuran / 6 h / 25 °C / 2280 Torr

4: 97 percent / H₂ / 10percent Pd/C / methanol / 3 h / 25 °C / 2280 Torr

5: LiOH, H₂O / methanol; tetrahydrofuran

6: EDCI / dimethylformamide / 25 °C

7: LiOH, H₂O / methanol; tetrahydrofuran / 25 °C

8: EDCI / CH₂Cl₂ / 25 °C

9: 3.0M HCl / ethyl acetate

With hydrogenchloride; lithium hydroxide; diphenyl-phosphinic acid; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00311a019

Reference yield:

: 161634-73-7
trans-3-(4-iodophenyl)-2-propenoic acid ethyl ester

: 120363-35-1
(S)-2-(3-{4-[3-(2-Amino-ethyl)-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid pentafluorophenyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

2: 97 percent / H₂ / 10percent Pd/C / methanol / 3 h / 25 °C / 2280 Torr

3: LiOH, H₂O / methanol; tetrahydrofuran

4: EDCI / dimethylformamide / 25 °C

5: LiOH, H₂O / methanol; tetrahydrofuran / 25 °C

6: EDCI / CH₂Cl₂ / 25 °C

7: 3.0M HCl / ethyl acetate

With hydrogenchloride; lithium hydroxide; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00311a019