{3-[5-(4-fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-propyl}-methyl-amine

Base Information

Chemical Name:{3-[5-(4-fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-propyl}-methyl-amine
CAS No.:888319-00-4
Molecular Formula:C₁₉H₂₀FN₃
Molecular Weight:309.386
Hs Code.:

{3-[5-(4-fluoro-phenyl)-4-pyridin-4-yl-1<i>H</i>-pyrrol-2-yl]-propyl}-methyl-amine

Synonyms:{3-[5-(4-fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-propyl}-methyl-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of {3-[5-(4-fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-propyl}-methyl-amine

Chemical Property:

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Technology Process of {3-[5-(4-fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-propyl}-methyl-amine

There total 7 articles about {3-[5-(4-fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-propyl}-methyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5105-78-2
4-(benzyloxycarbonylamino)butyric acid

: 888319-00-4
{3-[5-(4-fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-propyl}-methyl-amine

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / dimethylformamide

2: n-BuLi / tetrahydrofuran / -78 °C

3: K₂CO₃ / acetonitrile

4: thiazolium iodide; Et₃N / ethanol / Heating

5: ammonium acetate; acetic acid / 90 °C

6: lithium aluminium hydride / tetrahydrofuran / Heating

With ammonium acetate; lithium aluminium tetrahydride; n-butyllithium; thiazolium iodide; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile; 3: Horner-Emmons reaction;
DOI:10.1016/j.bmcl.2006.01.041

Reference yield:

: {3-[5-(4-fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-propyl}-carbamic acid benzyl ester

: 888319-00-4
{3-[5-(4-fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-propyl}-methyl-amine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;
DOI:10.1016/j.bmcl.2006.01.041

Reference yield:

: 888318-97-6
(5-benzyloxycarbonylamino-2-oxo-pentyl)-phosphonic acid dimethyl ester

: 888319-00-4
{3-[5-(4-fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-propyl}-methyl-amine

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / acetonitrile

2: thiazolium iodide; Et₃N / ethanol / Heating

3: ammonium acetate; acetic acid / 90 °C

4: lithium aluminium hydride / tetrahydrofuran / Heating

With ammonium acetate; lithium aluminium tetrahydride; thiazolium iodide; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; ethanol; acetonitrile; 1: Horner-Emmons reaction;
DOI:10.1016/j.bmcl.2006.01.041