4-Methoxy-2,2-dicarbethoxy-6,7-methylenedioxy-1-(3',4',5'-trimethoxyphenyl)tetralin

Base Information

• Chemical Name: 4-Methoxy-2,2-dicarbethoxy-6,7-methylenedioxy-1-(3',4',5'-trimethoxyphenyl)tetralin
• CAS No.: 81701-18-0
• Molecular Formula: C₂₇H₃₂O₁₀
• Molecular Weight: 516.545
• Mol file: 81701-18-0.mol

Synonyms:4-Methoxy-2,2-dicarbethoxy-6,7-methylenedioxy-1-(3',4',5'-trimethoxyphenyl)tetralin

Chemical Property of 4-Methoxy-2,2-dicarbethoxy-6,7-methylenedioxy-1-(3',4',5'-trimethoxyphenyl)tetralin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Methoxy-2,2-dicarbethoxy-6,7-methylenedioxy-1-(3',4',5'-trimethoxyphenyl)tetralin

There total 1 articles about 4-Methoxy-2,2-dicarbethoxy-6,7-methylenedioxy-1-(3',4',5'-trimethoxyphenyl)tetralin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-dimethoxyethane (110-71-4) + diethyl(3,4,5-trimethoxyphenyl)methylenemalonate + 5-bromo-6-(2-bromo-1-methoxyethyl)benzo[d][1,3]dioxole (81701-17-9) → 4-Methoxy-2,2-dicarbethoxy-6,7-methylenedioxy-1-(3',4',5'-trimethoxyphenyl)tetralin (81701-18-0)

Guidance literature:

With tert.-butyl lithium; In tetrahydrofuran; pentane;

Reference yield:

4-Methoxy-2,2-dicarbethoxy-6,7-methylenedioxy-1-(3',4',5'-trimethoxyphenyl)tetralin (81701-18-0) → 8-Hydroxy-5-(3,4,5-trimethoxy-phenyl)-7,8-dihydro-5H-naphtho[2,3-d][1,3]dioxole-6,6-dicarboxylic acid diethyl ester (77461-26-8,77461-27-9)

Guidance literature:

With trifluoroacetic acid; at -10 ℃; for 0.0833333h;

DOI:10.1021/jo00326a056

Reference yield:

4-Methoxy-2,2-dicarbethoxy-6,7-methylenedioxy-1-(3',4',5'-trimethoxyphenyl)tetralin (81701-18-0) → diethyl 8-oxo-5-(3,4,5-trimethoxyphenyl)-7,8-dihydronaphtho-[2,3-d][1,3]dioxole-6,6(5H)-dicarboxylate (64897-37-6)

Guidance literature:

Multi-step reaction with 2 steps

1: CF₃CO₂H / 0.08 h / -10 °C

2: 86 percent / C₅H₅N*HCl*CrO₃ / CH₂Cl₂ / 1 h / Ambient temperature

With Pyr*CrO₃*HCl; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jo00326a056

upstream raw materials:

1,2-dimethoxyethane

5-bromo-6-(2-bromo-1-methoxyethyl)benzo[d][1,3]dioxole

Downstream raw materials:

8-Hydroxy-5-(3,4,5-trimethoxy-phenyl)-7,8-dihydro-5H-naphtho[2,3-d][1,3]dioxole-6,6-dicarboxylic acid diethyl ester

diethyl 8-oxo-5-(3,4,5-trimethoxyphenyl)-7,8-dihydronaphtho-[2,3-d][1,3]dioxole-6,6(5H)-dicarboxylate

(5α,5aα,8aβ)-5,5a,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo<3',4':6,7>naphtho<2,3-d>-1,3-dioxole-6(5aH),9-(8aH)-dione

(5aS,8aS,9R)-5a-Hydroxymethyl-9-(3,4,5-trimethoxy-phenyl)-5a,6,8a,9-tetrahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5,8-dione