isopropyl 5-[(4,5-dimethyl-1H-pyrazole-3-carbonyl)amino]-2-(4-fluorophenyl)pyrrolo[2,3-b]pyridine-1-carboxylate

Base Information

Chemical Name:isopropyl 5-[(4,5-dimethyl-1H-pyrazole-3-carbonyl)amino]-2-(4-fluorophenyl)pyrrolo[2,3-b]pyridine-1-carboxylate
CAS No.:1616388-27-2
Molecular Formula:C₂₃H₂₂FN₅O₃
Molecular Weight:435.458
Hs Code.:

Synonyms:isopropyl 5-[(4,5-dimethyl-1H-pyrazole-3-carbonyl)amino]-2-(4-fluorophenyl)pyrrolo[2,3-b]pyridine-1-carboxylate

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Chemical Property of isopropyl 5-[(4,5-dimethyl-1H-pyrazole-3-carbonyl)amino]-2-(4-fluorophenyl)pyrrolo[2,3-b]pyridine-1-carboxylate

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Technology Process of isopropyl 5-[(4,5-dimethyl-1H-pyrazole-3-carbonyl)amino]-2-(4-fluorophenyl)pyrrolo[2,3-b]pyridine-1-carboxylate

There total 9 articles about isopropyl 5-[(4,5-dimethyl-1H-pyrazole-3-carbonyl)amino]-2-(4-fluorophenyl)pyrrolo[2,3-b]pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.9%

: 1616387-98-4
2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-amine

: 89831-40-3
3,4-dimethyl-2H-pyrazole-5-carboxylic acid

: 108-23-6
isopropyl chloroformate

: 1616388-27-2
isopropyl 5-[(4,5-dimethyl-1H-pyrazole-3-carbonyl)amino]-2-(4-fluorophenyl)pyrrolo[2,3-b]pyridine-1-carboxylate

Guidance literature:: With 4-methyl-morpholine; In toluene; at -20 - 20 ℃;

Reference yield:

: 1616387-97-3
3-((4-fluorophenyl)ethynyl)pyridine-2,5-diamine

: 1616388-27-2
isopropyl 5-[(4,5-dimethyl-1H-pyrazole-3-carbonyl)amino]-2-(4-fluorophenyl)pyrrolo[2,3-b]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 2 h / 80 °C

2: 4-methyl-morpholine / toluene / -20 - 20 °C

With 4-methyl-morpholine; potassium tert-butylate; In 1-methyl-pyrrolidin-2-one; toluene;

Reference yield:

: 1616388-26-1
tert-butyl N-[2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]carbamate

: 1616388-27-2
isopropyl 5-[(4,5-dimethyl-1H-pyrazole-3-carbonyl)amino]-2-(4-fluorophenyl)pyrrolo[2,3-b]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; water; dichloromethane / 2 h / 20 °C

2: 4-methyl-morpholine / toluene / -20 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; In 1,4-dioxane; dichloromethane; water; toluene;