5'-(4-(trifluoromethyl)phenyl)spiro[[1,3]dioxolane-2,3'-indolin]-2'-one

Base Information

Chemical Name:5'-(4-(trifluoromethyl)phenyl)spiro[[1,3]dioxolane-2,3'-indolin]-2'-one
CAS No.:1412900-36-7
Molecular Formula:C₁₇H₁₂F₃NO₃
Molecular Weight:335.282
Hs Code.:

Synonyms:5'-(4-(trifluoromethyl)phenyl)spiro[[1,3]dioxolane-2,3'-indolin]-2'-one

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Chemical Property of 5'-(4-(trifluoromethyl)phenyl)spiro[[1,3]dioxolane-2,3'-indolin]-2'-one

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Technology Process of 5'-(4-(trifluoromethyl)phenyl)spiro[[1,3]dioxolane-2,3'-indolin]-2'-one

There total 1 articles about 5'-(4-(trifluoromethyl)phenyl)spiro[[1,3]dioxolane-2,3'-indolin]-2'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 75822-54-7
5’-bromo-1‘,2’-dihydrospiro[1,3-dioxolane-2,3’-indole]-2’-one

: 1412900-36-7
5'-(4-(trifluoromethyl)phenyl)spiro[[1,3]dioxolane-2,3'-indolin]-2'-one

Guidance literature:: 5’-bromo-1‘,2’-dihydrospiro[1,3-dioxolane-2,3’-indole]-2’-one; With bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; at 20 ℃; for 0.25h; Inert atmosphere;

4-trifluoromethylphenylboronic acid; With sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; for 2h; Reflux; Inert atmosphere;
DOI:10.1016/j.tet.2012.09.036

Reference yield: 97.0%

: 1412900-36-7
5'-(4-(trifluoromethyl)phenyl)spiro[[1,3]dioxolane-2,3'-indolin]-2'-one

: 893736-59-9
5-(4-(trifluoromethyl)phenyl)indoline-2,3-dione

Guidance literature:: With hydrogenchloride; In methanol; for 4h; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2012.09.036

Reference yield:

: 1412900-36-7
5'-(4-(trifluoromethyl)phenyl)spiro[[1,3]dioxolane-2,3'-indolin]-2'-one

: 1412900-43-6
3-allyl-3-((2-bromophenyl)amino)-5-(4-(trifluoromethyl)phenyl)indolin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / methanol / 4 h / Inert atmosphere; Reflux

2: toluene-4-sulfonic acid / chloroform / 48 h / Inert atmosphere; Reflux

3: indium; sodium iodide / tetrahydrofuran / Inert atmosphere

With hydrogenchloride; indium; toluene-4-sulfonic acid; sodium iodide; In tetrahydrofuran; methanol; chloroform;
DOI:10.1016/j.tet.2012.09.036