3-allyl-3-((2-bromophenyl)amino)-5-(4-(trifluoromethyl)phenyl)indolin-2-one

Base Information

Chemical Name:3-allyl-3-((2-bromophenyl)amino)-5-(4-(trifluoromethyl)phenyl)indolin-2-one
CAS No.:1412900-43-6
Molecular Formula:C₂₄H₁₈BrF₃N₂O
Molecular Weight:487.319
Hs Code.:

Synonyms:3-allyl-3-((2-bromophenyl)amino)-5-(4-(trifluoromethyl)phenyl)indolin-2-one

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Chemical Property of 3-allyl-3-((2-bromophenyl)amino)-5-(4-(trifluoromethyl)phenyl)indolin-2-one

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Technology Process of 3-allyl-3-((2-bromophenyl)amino)-5-(4-(trifluoromethyl)phenyl)indolin-2-one

There total 6 articles about 3-allyl-3-((2-bromophenyl)amino)-5-(4-(trifluoromethyl)phenyl)indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 3-((2-bromophenyl)imino)-5-(4-(trifluoromethyl)phenyl)indolin-2-one

: 106-95-6
allyl bromide

: 1412900-43-6
3-allyl-3-((2-bromophenyl)amino)-5-(4-(trifluoromethyl)phenyl)indolin-2-one

Guidance literature:: With indium; sodium iodide; In tetrahydrofuran; Inert atmosphere;
DOI:10.1016/j.tet.2012.09.036

Reference yield:

: 75822-54-7
5’-bromo-1‘,2’-dihydrospiro[1,3-dioxolane-2,3’-indole]-2’-one

: 1412900-43-6
3-allyl-3-((2-bromophenyl)amino)-5-(4-(trifluoromethyl)phenyl)indolin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 0.25 h / 20 °C / Inert atmosphere

1.2: Suzuki Coupling / 2 h / Reflux; Inert atmosphere

2.1: hydrogenchloride / methanol / 4 h / Inert atmosphere; Reflux

3.1: toluene-4-sulfonic acid / chloroform / 48 h / Inert atmosphere; Reflux

4.1: indium; sodium iodide / tetrahydrofuran / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; indium; toluene-4-sulfonic acid; sodium iodide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; chloroform; 1.1: |Suzuki Coupling / 1.2: |Suzuki Coupling;
DOI:10.1016/j.tet.2012.09.036

Reference yield:

: 1412900-36-7
5'-(4-(trifluoromethyl)phenyl)spiro[[1,3]dioxolane-2,3'-indolin]-2'-one

: 1412900-43-6
3-allyl-3-((2-bromophenyl)amino)-5-(4-(trifluoromethyl)phenyl)indolin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / methanol / 4 h / Inert atmosphere; Reflux

2: toluene-4-sulfonic acid / chloroform / 48 h / Inert atmosphere; Reflux

3: indium; sodium iodide / tetrahydrofuran / Inert atmosphere

With hydrogenchloride; indium; toluene-4-sulfonic acid; sodium iodide; In tetrahydrofuran; methanol; chloroform;
DOI:10.1016/j.tet.2012.09.036