methyl 5-(2,2-dimethylpropionylamino)-6-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Base Information

Chemical Name:methyl 5-(2,2-dimethylpropionylamino)-6-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate
CAS No.:1609122-63-5
Molecular Formula:C₁₇H₂₀FNO₄
Molecular Weight:321.349
Hs Code.:

Synonyms:methyl 5-(2,2-dimethylpropionylamino)-6-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

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Chemical Property of methyl 5-(2,2-dimethylpropionylamino)-6-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

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Technology Process of methyl 5-(2,2-dimethylpropionylamino)-6-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

There total 1 articles about methyl 5-(2,2-dimethylpropionylamino)-6-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62257-16-3
5-hydroxy-2-fluoroaniline

: 1609122-63-5
methyl 5-(2,2-dimethylpropionylamino)-6-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine / 1 h / 0 - 20 °C

2.1: pyridinium p-toluenesulfonate / dichloromethane / Reflux

3.1: n-butyllithium / hexane; tetrahydrofuran / 1.17 h / -78 - 0 °C

3.2: -78 - 20 °C

3.3: 20 °C

4.1: diazomethyl-trimethyl-silane / toluene / 4 h / 0 - 20 °C

5.1: potassium carbonate / toluene; acetone / 6 h / Reflux

6.1: bis[(trifluoromethanesulfonyl)imidate]-2-(dicyclohexyl(2’,6’-dimethoxybiphenyl))phosphine gold(I) / toluene / 3 h / 85 °C

7.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water / 3 h / 60 °C

8.1: zinc; ammonium chloride / ethanol / Reflux

With pyridine; n-butyllithium; bis[(trifluoromethanesulfonyl)imidate]-2-(dicyclohexyl(2’,6’-dimethoxybiphenyl))phosphine gold(I); N-benzyl-N,N,N-triethylammonium chloride; pyridinium p-toluenesulfonate; potassium carbonate; ammonium chloride; sodium hydroxide; zinc; diazomethyl-trimethyl-silane; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; acetone; toluene;

Reference yield:

: 1609122-63-5
methyl 5-(2,2-dimethylpropionylamino)-6-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1609122-61-3
methyl (2-bromo-4-fluorobenzenesulfonylamino)-6-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid; methanol / Reflux

2: sodium hexamethyldisilazane / tetrahydrofuran / 1 h

With methanol; sulfuric acid; sodium hexamethyldisilazane; In tetrahydrofuran;

Reference yield:

: 1609122-63-5
methyl 5-(2,2-dimethylpropionylamino)-6-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1609122-60-2
methyl 5-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-6-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; methanol / Reflux

2: sodium hexamethyldisilazane / tetrahydrofuran / 1 h

3: tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / dimethyl sulfoxide; 1,4-dioxane / 80 °C

4: lithium hydroxide; water / 1,4-dioxane / 6 h / 90 °C

With methanol; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; water; sodium hexamethyldisilazane; lithium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide;