Technology Process of 4,5,6-tri-O-benzyl-1,3-O-methylidenemyoinositol
There total 4 articles about 4,5,6-tri-O-benzyl-1,3-O-methylidenemyoinositol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4,6-di-O-benzyl-2-O-(p-methoxybenzyl)-myo-inositol-1,3,5-O-orthoformate;
With
diisobutylaluminium hydride;
In
dichloromethane; toluene;
at 20 ℃;
for 4h;
Inert atmosphere;
Cooling with ice;
With
ammonium chloride; rochelle salt;
In
dichloromethane; water; ethyl acetate; toluene;
at 20 ℃;
for 12h;
benzyl bromide;
Further stages;
DOI:10.1016/j.tet.2011.08.027
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium hydride / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere
1.2: 24 h / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 20 °C / Inert atmosphere; Cooling with ice
3.1: diisobutylaluminium hydride / dichloromethane; toluene / 4 h / 20 °C / Inert atmosphere; Cooling with ice
3.2: 12 h / 20 °C
With
lithium hydride; sodium hydride; diisobutylaluminium hydride;
In
dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1016/j.tet.2011.08.027
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 20 °C / Inert atmosphere; Cooling with ice
2.1: diisobutylaluminium hydride / dichloromethane; toluene / 4 h / 20 °C / Inert atmosphere; Cooling with ice
2.2: 12 h / 20 °C
With
sodium hydride; diisobutylaluminium hydride;
In
dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1016/j.tet.2011.08.027
