(S)-2-Amino-N-[2-(tert-butyl-dimethyl-silanyloxy)-1,1-bis-(tert-butyl-dimethyl-silanyloxymethyl)-ethyl]-3-(1-trityl-1H-imidazol-4-yl)-propionamide

Base Information

• Chemical Name: (S)-2-Amino-N-[2-(tert-butyl-dimethyl-silanyloxy)-1,1-bis-(tert-butyl-dimethyl-silanyloxymethyl)-ethyl]-3-(1-trityl-1H-imidazol-4-yl)-propionamide
• CAS No.: 170797-86-1
• Molecular Formula: C₄₇H₇₄N₄O₄Si₃
• Molecular Weight: 843.385
• Mol file: 170797-86-1.mol

Synonyms:(S)-2-Amino-N-[2-(tert-butyl-dimethyl-silanyloxy)-1,1-bis-(tert-butyl-dimethyl-silanyloxymethyl)-ethyl]-3-(1-trityl-1H-imidazol-4-yl)-propionamide

Chemical Property of (S)-2-Amino-N-[2-(tert-butyl-dimethyl-silanyloxy)-1,1-bis-(tert-butyl-dimethyl-silanyloxymethyl)-ethyl]-3-(1-trityl-1H-imidazol-4-yl)-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Amino-N-[2-(tert-butyl-dimethyl-silanyloxy)-1,1-bis-(tert-butyl-dimethyl-silanyloxymethyl)-ethyl]-3-(1-trityl-1H-imidazol-4-yl)-propionamide

There total 3 articles about (S)-2-Amino-N-[2-(tert-butyl-dimethyl-silanyloxy)-1,1-bis-(tert-butyl-dimethyl-silanyloxymethyl)-ethyl]-3-(1-trityl-1H-imidazol-4-yl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

[(S)-1-[2-(tert-Butyl-dimethyl-silanyloxy)-1,1-bis-(tert-butyl-dimethyl-silanyloxymethyl)-ethylcarbamoyl]-2-(1-trityl-1H-imidazol-4-yl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester (170797-85-0) → (S)-2-Amino-N-[2-(tert-butyl-dimethyl-silanyloxy)-1,1-bis-(tert-butyl-dimethyl-silanyloxymethyl)-ethyl]-3-(1-trityl-1H-imidazol-4-yl)-propionamide (170797-86-1)

Guidance literature:

With piperidine;

DOI:10.1016/00404-0399(50)1064O-

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → (S)-2-Amino-N-[2-(tert-butyl-dimethyl-silanyloxy)-1,1-bis-(tert-butyl-dimethyl-silanyloxymethyl)-ethyl]-3-(1-trityl-1H-imidazol-4-yl)-propionamide (170797-86-1)

Guidance literature:

Multi-step reaction with 3 steps

2: 94 percent / 1,3-dicyclohexylcarbodiimide, 1-hydroxy benzotriazole / dimethylformamide

3: 97 percent / piperidine

With piperidine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1016/00404-0399(50)1064O-

Reference yield:

6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2,3,3,9,9,10,10-octamethyl-4,8-dioxa-3,9-disilaundecan-6-amine (102522-47-4) → (S)-2-Amino-N-[2-(tert-butyl-dimethyl-silanyloxy)-1,1-bis-(tert-butyl-dimethyl-silanyloxymethyl)-ethyl]-3-(1-trityl-1H-imidazol-4-yl)-propionamide (170797-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / 1,3-dicyclohexylcarbodiimide, 1-hydroxy benzotriazole / dimethylformamide

2: 97 percent / piperidine

With piperidine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1016/00404-0399(50)1064O-

upstream raw materials:

[(S)-1-[2-(tert-Butyl-dimethyl-silanyloxy)-1,1-bis-(tert-butyl-dimethyl-silanyloxymethyl)-ethylcarbamoyl]-2-(1-trityl-1H-imidazol-4-yl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

tert-butyldimethylsilyl chloride

6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2,3,3,9,9,10,10-octamethyl-4,8-dioxa-3,9-disilaundecan-6-amine

Downstream raw materials:

[2-(Benzyloxycarbonyl-{6-[(S)-1-[2-(tert-butyl-dimethyl-silanyloxy)-1,1-bis-(tert-butyl-dimethyl-silanyloxymethyl)-ethylcarbamoyl]-2-(1-trityl-1H-imidazol-4-yl)-ethylcarbamoyl]-pyridin-2-ylmethyl}-amino)-ethyl]-carbamic acid benzyl ester