3-(4-(4-(3-(3-chlorophenyl)ureido)thieno[3,2-d]pyrimidin-7-yl)phenyl)propanoic acid

Base Information

Chemical Name:3-(4-(4-(3-(3-chlorophenyl)ureido)thieno[3,2-d]pyrimidin-7-yl)phenyl)propanoic acid
CAS No.:1421230-68-3
Molecular Formula:C₂₂H₁₇ClN₄O₃S
Molecular Weight:452.921
Hs Code.:

Synonyms:3-(4-(4-(3-(3-chlorophenyl)ureido)thieno[3,2-d]pyrimidin-7-yl)phenyl)propanoic acid

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Chemical Property of 3-(4-(4-(3-(3-chlorophenyl)ureido)thieno[3,2-d]pyrimidin-7-yl)phenyl)propanoic acid

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Technology Process of 3-(4-(4-(3-(3-chlorophenyl)ureido)thieno[3,2-d]pyrimidin-7-yl)phenyl)propanoic acid

There total 7 articles about 3-(4-(4-(3-(3-chlorophenyl)ureido)thieno[3,2-d]pyrimidin-7-yl)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421230-76-3
methyl 3-(4-(4-aminothieno[3,2-d]pyrimidin-7-yl)phenyl)propanoate

: 2909-38-8
m-chlorophenyl isocyanate

: 1421230-68-3
3-(4-(4-(3-(3-chlorophenyl)ureido)thieno[3,2-d]pyrimidin-7-yl)phenyl)propanoic acid

Guidance literature:: methyl 3-(4-(4-aminothieno[3,2-d]pyrimidin-7-yl)phenyl)propanoate; m-chlorophenyl isocyanate; In tetrahydrofuran; at 20 ℃; for 24h;

With water; sodium hydroxide; In methanol; for 2h;

Reference yield:

: 31169-27-4
7-bromo-4-chlorothieno[3,2-d]pyrimidine

: 1421230-68-3
3-(4-(4-(3-(3-chlorophenyl)ureido)thieno[3,2-d]pyrimidin-7-yl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 13 h / 10 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water / 100 °C

3.1: fluorosulfonyl fluoride / dichloromethane; acetonitrile / 1 h / 0 °C

4.1: ammonia / isopropyl alcohol / 100 °C

5.1: tetrahydrofuran / 24 h / 20 °C

5.2: 2 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; fluorosulfonyl fluoride; ammonia; sodium carbonate; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 31169-25-2
7-bromothieno[3,2-d]pyrimidine-4(3H)-one

: 1421230-68-3
3-(4-(4-(3-(3-chlorophenyl)ureido)thieno[3,2-d]pyrimidin-7-yl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / trichlorophosphate / 3 h / 150 °C

2.1: tetrahydrofuran / 13 h / 10 - 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water / 100 °C

4.1: fluorosulfonyl fluoride / dichloromethane; acetonitrile / 1 h / 0 °C

5.1: ammonia / isopropyl alcohol / 100 °C

6.1: tetrahydrofuran / 24 h / 20 °C

6.2: 2 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; fluorosulfonyl fluoride; ammonia; sodium carbonate; trichlorophosphate; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; acetonitrile; trichlorophosphate;