(+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-5-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-5-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:80601-80-5
Molecular Formula:C₂₉H₃₃NO₇
Molecular Weight:507.584
Hs Code.:

Synonyms:(+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-5-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of (+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-5-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

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Technology Process of (+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-5-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

There total 4 articles about (+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-5-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 80601-80-5
(+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-5-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / NaHCO₃ / CHCl₃; H₂O / 1 h / 5 °C / then 2 h room temperature

2: 90 percent / Et₃N / acetonitrile / 2 h / Ambient temperature

3: 1.) Me₂SO₄, 2.) NaBH₃CN / 1.) Et₂O, room temperature, 2 h, 2.) HMPA, 70 deg C, 3 h

With sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine; dimethyl sulfate; In chloroform; water; acetonitrile;
DOI:10.1248/cpb.29.2816

Reference yield:

: 80601-77-0
(+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

: 80601-80-5
(+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-5-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Et₃N / acetonitrile / 2 h / Ambient temperature

2: 1.) Me₂SO₄, 2.) NaBH₃CN / 1.) Et₂O, room temperature, 2 h, 2.) HMPA, 70 deg C, 3 h

With sodium cyanoborohydride; triethylamine; dimethyl sulfate; In acetonitrile;
DOI:10.1248/cpb.29.2816

Reference yield:

: 32860-52-9
(+/-)-6-hydroxy-7-methoxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 80601-80-5
(+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-5-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / NaHCO₃ / CHCl₃; H₂O / 1 h / 5 °C / then 2 h room temperature

2: 90 percent / Et₃N / acetonitrile / 2 h / Ambient temperature

3: 1.) Me₂SO₄, 2.) NaBH₃CN / 1.) Et₂O, room temperature, 2 h, 2.) HMPA, 70 deg C, 3 h

With sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine; dimethyl sulfate; In chloroform; water; acetonitrile;
DOI:10.1248/cpb.29.2816