(+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:80601-77-0
Molecular Formula:C₂₈H₃₁NO₇
Molecular Weight:493.557
Hs Code.:

Synonyms:(+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of (+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

There total 1 articles about (+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 32860-52-9
(+/-)-6-hydroxy-7-methoxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 80601-77-0
(+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sodium hydrogencarbonate; In chloroform; water; at 5 ℃; for 1h; then 2 h room temperature;
DOI:10.1248/cpb.29.2816

Reference yield: 90.0%

: 30354-18-8
N,N-dimethyl(methylene)ammonium chloride

: 80601-77-0
(+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

: 80601-79-2
(+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-5-dimethylaminomethyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With triethylamine; In acetonitrile; for 2h; Ambient temperature;
DOI:10.1248/cpb.29.2816

Reference yield:

: 80601-77-0
(+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

: 80601-80-5
(+/-)-N-benzyloxycarbonyl-6-hydroxy-7-methoxy-5-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Et₃N / acetonitrile / 2 h / Ambient temperature

2: 1.) Me₂SO₄, 2.) NaBH₃CN / 1.) Et₂O, room temperature, 2 h, 2.) HMPA, 70 deg C, 3 h

With sodium cyanoborohydride; triethylamine; dimethyl sulfate; In acetonitrile;
DOI:10.1248/cpb.29.2816